Human De Novo Mutation Rates Mapped Across Generations

A groundbreaking investigation into the mutation dynamics of tandem repeats (TRs) within the human genome has revealed unprecedented insights into their de novo mutation rates, patterns of inheritance, and recurrence across multiple generations. Employing state-of-the-art high-fidelity (HiFi) long-read sequencing combined with complementary sequencing technologies, researchers meticulously geno