Unlocking Complex Sulfur Molecules: A Novel Approach for Synthesis of Functionalized Benzenethiol Equivalents

Novel Synthesis Method Unlocking Complex Sulfur Molecules: A Novel Approach for Synthesis of Functionalized Benzenethiol Equivalents

2024-06-06 Source: Tokyo University of Science 3 min Reading Time

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Organosulfur skeletons are crucial in many fields, including pharmaceuticals and electronics. Synthesizing organosulfur skeletons requires o-bromobenzenethiols. However, conventional methods face challenges due to quick oxidation and formation of highly reactive intermediates. In a new study, researchers from Japan developed a new method for synthesizing o-bromobenzenethiols from aryne intermediates via bromothiolation. This method can pave the way for the synthesis of new organosulfur compounds with applications in diverse fields.

Synthesizing o-bromobenzenethiols from aryne intermediates: This innovative method involves bromothiolation of aryne intermediates, resulting in the formation of highly functional o-bromobenzenethiols, which can be subsequently used to prepare diverse organosulfur compounds.
(Source: Suguru Yoshida from Tokyo University of Science)

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