Chimerix: A High-Risk 'Lottery Ticket'

You can't unscramble the egg no matter your wisdom and determination" - Kaleb Kilton.

It has been exactly one year since our last look at Chimerix, Inc. (NASDAQ:CMRX). We concluded that article with the following summary:

Chimerix is an interesting 'sum of the parts' story currently. Its roughly $275 million exceeds its current market cap by some $80 million. It has one late-stage asset in development in ONC201 as well as earlier stage compounds in its pipeline. While not adding to my small stake in CMRX, I plan to retain my 'watch item' holding in this stock, pending further developments."

The stock has largely stayed in a trading range over the past year. However, the equity recently was initiated as a new buy at an analyst firm, and it put out a new investor presentation. Therefore, we will circle back to this small developmental firm via the updated analysis below.

Company Overview:

This small biotech concern is based in Durham, NC. The company has several compounds currently in development. Chimerix is focused on developing medicines that meaningfully improve and extend the lives of patients facing deadly diseases.

Chimerix had a lipid conjugate through inhibition of viral DNA synthesis that was developed and approved in mid-2021 as a medical countermeasure for smallpox, called TEMBEXA. The company sold and has transitioned the rights to Tembexa to Emergent BioSolutions (EBS). The stock trades at around $1.50 a share and sports an approximate market capitalization of $125 million.

The company is evaluating several assets within its pipeline via partnerships. However, by far Chimera's most important potential asset is wholly owned ONC201. The compound is being focused to treat brain tumors with H3 K27M-mutations. In pre-clinical studies, ONC201 was shown the ability to reverse H3K27 trimethyl loss, being the first known example of a candidate to do so. This is a characteristic which has been linked to tumor growth and poor prognosis.

Here is how the company describes ONC201 on its website:

ONC201 is the founding member of the imipridone class of anti-cancer small molecules which selectively targets Dopamine Receptor D2 (DRD2) and ClpP. ONC201-mediated cell death occurs via induction of the integrated stress response and upregulation of apoptotic factors, such as tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). It is dosed orally and has been well-tolerated and shown clinical activity in Phase I and II trials for specific advanced cancers. ONC201 has been shown to preferentially induce cell death in cancer cells by binding to and differentially altering activity of DRD2 and ClpP as shown schematically below:"

The company laid off a quarter of their workforce in late 2022 as a result of moving Tembexa to Emergent and as part of their strategic refocus to their oncology pipeline. Phase 2 data produced durable tumor responses and an overall survival advantage compared to other therapies.

Chimerix has kicked off a pivotal Phase 3 study, "ACTION." Enrollment is currently ongoing at nine study sites globally. The first efficacy analysis from this trial is due out early 2025, and it will include an initial overall survival assessment.

The company also has ONC206 is much earlier development. It is also targeting H3K27M. That compound is being evaluated within an open-label dose escalation study to run into the first half of 2024. ONC206 is targeting a much larger potential population than ONC201's potential glioma indication.

Analyst Commentary & Balance Sheet:

On May 22nd, Robert W. Baird initiated the shares as a new Outperform with a $7 price target, based on its view that Chimera's phase 3 glioma candidate has a high probability of success (65%). This is the only analyst firm rating I can find on CMRX over the past year.

Approximately five percent of the outstanding float in the shares is currently held short. Several insiders including the CEO and CFO made some small insider purchases in May totaling nearly $200,000 collectively. After posting a net loss of $21.4 million for the first quarter, management described its balance sheet as thus:

Includes $246.1 million of capital available to fund operations, approximately 88.6 million outstanding shares of common stock and no outstanding debt.

Leadership expects to end FY2023 with at least $200 million of cash and marketable securities on its balance sheet. It believes it has funding in place to get Chimerix into 2027 given current planned activities.

Verdict:

Chimerix, Inc. stock currently sells for under the net cash on its balance sheet. This is a stock for the patient investor, as the primary endpoint data readouts from the ACTION study will not be out until 2025. Provided data is good from the dose escalation study around ONC206, a trial to test efficacy should also kick off in 2025.

If development of ONC201 is successful, Chimerix, Inc.'s stock would seem to be set up to be a "multi-bagger" given the potential market, and what should be a rapid ramp-up. The downside is potential commercialization is 2026 at the earliest. Therefore, CMRX remains a high risk/high reward "lottery ticket." It continues to merit a small "watch item" holding for aggressive investors within a well-diversified biotech portfolio.

It is those who cannot defend their argument who seek to silence those who can." - Craig D. Lounsbrough.

Live Chat on The Biotech Forum has been dominated by discussion of lucrative buy-write or covered call opportunities on selected biotech stocks over the past several months. To see what I and the other season biotech investors are targeting as trading ideas real-time, just join our community at The Biotech Forum by clicking HERE.