Biden Secured Trillions in Domestic Spending. Now Comes the Hard Part.

WASHINGTON—President Biden is reorienting swaths of the federal government to focus on implementing the sweeping legislation he signed into law in his first two years in office and directing his senior advisers to guard against the waste and fraud that have bedeviled previous government programs.

Mr. Biden is staking his reputation—and legacy—on spending nearly $2 trillion in taxpayer money efficiently and effectively. Done well, the effort could reshape the economy and help him win a second term. Any mistakes could threaten Mr. Biden’s 2024 re-election odds amid a pledge by congressional Republicans to conduct rigorous oversight of the administration’s spending spree.