Moderna, Merck Show Progress Toward Cancer Vaccines

An mRNA shot helped prevent relapse in high-risk melanoma patients

A Moderna and Merck trial offers some of the strongest evidence yet of vaccines that could benefit cancer patients.  Photo: Adam Glanzman/Bloomberg

Moderna Inc. and Merck & Co.’s cancer vaccine helped prevent relapse for melanoma patients, results from a midstage trial showed, demonstrating progress in the pursuit of shots to ward off cancer by jump-starting the immune system. 

About 79% of high-risk melanoma patients who got the personalized vaccine and Merck’s immunotherapy Keytruda were alive and cancer-free at 18 months, compared with about 62% of patients who received immunotherapy alone, researchers said Sunday. The 157-person trial offers some of the strongest evidence yet that such vaccines could benefit cancer patients. 

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