Multiscale Polyvalent Biosensing using DNA Nanotechnology & Electrochemistry

Dr. Philip S. Lukeman 
Associate Professor
School of Liberal Arts and Sciences
St. John’s University, Queens, NY

Abstract:

We will describe here the utilization of DNA nanotechnology to construct three different electrochemical biosensor platforms that can:

• Be used to detect a wide range of targets (DNA, proteins) by swapping independent, modular analyte binding domains and reporter domains

• Detect 100 nm+ scale targets and discriminate intact target vs subunit binding
• Utilize electron transfer rate as a measure of polyvalent binding