A protein response that takes place at the cellular level as a result of ageing includes a balance between oxidants and antioxidants, low-grade inflammation, and is the cause of many medical conditions. Exercise has been found to balance oxidants like free radicals that accumulate in cells and damage DNA, regulate the inflammatory response, and improve the mechanism by which cells defend themselves against these stressors. In addition, resistance exercise is advised for older persons in order to support the maintenance of muscle, flexibility, and balance. Aging and related diseases are associated with alterations in oxidative status and low-grade inflammation, as well as a decreased endoplasmic reticulum (ER) unfolded protein response (UPR).