Signs of inflammation in the blood reliably predict and identify severe depression in pregnancy, reports a new study. The team's analysis established a set of 15 biological markers found in the blood that can predict if pregnant women will experience significant depressive symptoms with 83% accuracy. The findings could give physicians a much-needed tool to identify women who may be at risk for depression and better tailor their care throughout pregnancy. Nearly one in five new mothers experience severe depression during or after pregnancy and an estimated 14% have suicidal thoughts. Inflammation can lead to worsening depressive symptoms, and pregnancy is a major inflammatory event.