Apparently, according to science, it's no longer cool to say, 'how are you,' to someone. According to The Harvard Study of Communications, a first impression is formed within seven seconds, so asking how you are may not be in our best interests. A study was conducted to investigate how successful people make small talk. It was found that the best way to make the most of small talk is to ask the other person follow-up questions [1].
An analysis of over 300 online conversations by researchers found that those who were asked more meaningful follow-up questions such as questions other than "how are you?" and "what do you do?" rated the other party as more likeable.
"When people are instructed to ask more questions, they are perceived as higher in responsiveness, an interpersonal construct that captures listening, understanding, validation and care," the researchers wrote [3].
Regardless of what you say, your tone of voice, facial expression, and eye contact will convey far more information than any words you use. You should look at the other person when you speak in person, not at the conference table or the wall. Smiling will make your voice sound warmer when you are on the phone. Remember - how you say something is more important than what you say.