With a comfortable lead from the first leg, Chelsea did not take any risk and was content to patiently wait for an opening with a fluid passing game. The visitors gradually grew into the match and Mateo Kovacic caused real problems to the Lille backline with his bursting runs and quick dribbles.
There was a change in dynamics soon after the half-hour mark when Andreas Christensen had to leave the pitch injured. He was replaced by Trevoh Chalobah, who was immediately nutmegged by Jonathan David on the side of the area and conceded a free kick.
Lille's opener came from the subsequent move as Jorginho involuntarily blocked the ball with his arm in the area, prompting Lille players to shout for a penalty that was awarded following a VAR check.
Ylmaz took it and fired the ball into the top corner past Chelsea goalkeeper Edouard Mendy in the 38th minute.
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Lille could not hang onto the lead for long, though. The hosts were punished after Jorginho picked out Pulisic in the box with a perfectly weighted pass that the American forward slotted into the net at the far post from a tight angle.
You deserved a good evening!#LilChe pic.twitter.com/j1obMuh3KH — Chelsea FC (@ChelseaFC) March 16, 2022
After the break, Lille threatened again with a fine header from Ylmaz that sailed just inches wide. Portuguese midfielder Xeka came even closer in the 64th minute with a powerful header from Ylmaz's pinpointed cross that crashed onto the post.
Lille's hopes were dashed for good when Azpilicueta beat goalkeeper Leo Jardim at the end of a good spell of possession. Left unmarked, the former Marseille player connected with a cross from Mount and sent the ball into the net with his right knee.
Timothy Weah came off the bench for Lille in the 58th minute, making it the first time two Americans played against each other in a Champions League knockout game