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Juventus made a change at half-time with Leonardo Bonucci replacing Alex Sandro in defence, and the visitors had the first chance of the second half with Alvaro Morata firing just wide of the far post, Xinhua reports.
Villarreal played with slightly more patience than the first half, and Lo Celso forced a save from Wojciech Szczesny in the 56th minute.
Parejo equalised for the home side 10 minutes later, as he ghosted into space between Juventus' three central defenders to collect a pass from Capoue before scoring with a left-footed shot.
What a start for Champions League debutant Dušan Vlahović!#UCL pic.twitter.com/w7Q3aSkqhO — UEFA Champions League (@ChampionsLeague) February 22, 2022
Tensions increased with the game well-balanced, as both Villarreal keeper Geronimo Rulli and Juventus' Adrien Rabiot were shown yellow cards after the French midfielder tackled over the ball.
Either side could have won the game in the closing minutes with Rulli saving well from Vlahovic at one end before Bonucci did well to clear ahead of Lo Celso and Yeremi Pino at the other to leave everything to be decided in the second leg in Turin.