Approval of mixing and matching of COVID booster shots by FDA is yet another confirmation of efficacy of vaccine cocktail approach pioneered by the Russian Sputnik V vaccine

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  • Sputnik V pioneered the heterologous boosting approach through combination of human adenovirus serotype 26 as the first component and human adenovirus serotype 5 as the second component.
  • RDIF took the lead in initiating partnerships with global vaccine producers for combination trials of the first component of Sputnik V (the Sputnik Light vaccine) and other vaccines.
  • Combination trials between Sputnik Light and vaccines by AstraZeneca, Sinopharm, Moderna and Cansino confirm Sputnik Light as a universal booster shot with high safety and immunogenicity profile.
  • One-shot Sputnik Light is a highly effective vaccine when used both on standalone basis and applied as a booster. Sputnik Light is authorized in more than 15 countries, with ongoing registration processes in another 30 countries.

MOSCOW, Oct. 21, 2021 /PRNewswire/ — Following the decision by the U.S. Food and Drug Administration allowing individuals to receive booster shots that are different from their first COVID-19 vaccine doses, the Russian Direct Investment Fund (RDIF, Russia’s sovereign wealth fund) reiterates that the heterologous boosting approach pioneered by the Russian Sputnik V vaccine is one of the best solutions against the pandemic. The mix&match approach pioneered by Sputnik V strengthens and lengthens immune response, increases vaccine efficacy against new mutations and provides flexibility to vaccination efforts worldwide.

FDA’s decision to approve mixing and matching COVID booster shots in the U.S. is yet another confirmation of efficacy of vaccine cocktail approach at the core of Sputnik V – the world’s first registered coronavirus vaccine.

I. Sputnik V as the global pioneer in heterologous boosting

Sputnik V combines human adenovirus serotype 26 as the first component and human adenovirus serotype 5 as the second component. Heterologous boosting approach has proven to be successful against coronavirus: Sputnik V has confirmed overall efficacy 91.4% providing for creation of a strong and durable immunity. Sputnik V’s efficacy against infection with the Delta variant is 83% and 94% against hospitalization. To date Sputnik V has been registered in 70 countries in various parts of the world with total population of over 4 billion people.

II. RDIF’s leading role in initiating partnerships with other COVID vaccine producers

As part of the global effort to join forces in the fight against the pandemic, RDIF took the lead in initiating partnerships with other vaccine producers to conduct joint mix&match studies. The world’s first partnership of this kind was concluded in December 2020 with AstraZeneca aimed at conducting joint clinical trial of a combination of AstraZeneca vaccine and the first component of Sputnik V (the one-shot Sputnik Light vaccine). To date joint clinical studies between Sputnik Light and AstraZeneca are successfully ongoing in a number of countries (Argentina, Azerbaijan, Russia, UAE), demonstrating high safety and immunogenicity profile of the combination.

III. The first component of Sputnik V (Sputnik Light) as a universal booster for other COVID vaccines

One-shot Sputnik Light is a highly effective vaccine when used both on standalone basis and applied as a booster. Sputnik Light has been authorized in more than 15 countries with the registration process ongoing in a further 30 countries.

The latest findings by the Gamaleya Center based on data from 28,000 subjects in Moscow have demonstrated the Sputnik Light vaccine administered standalone has 70% efficacy against infection from the Delta variant of coronavirus during the first three months after vaccination. The vaccine is 75% effective among subjects under the age of 60.

Efficacy of one-shot Sputnik Light as a booster against Delta variant for other vaccines will be close to the efficacy against the Delta variant of the Sputnik V vaccine: over 83% against infection and over 94% against hospitalization.

Sputnik Light has demonstrated a superior efficacy compared with some two-shot vaccines, which have shown a major decline in efficacy against the Delta variant to less than 50% five months after injection. Standalone use of Sputnik Light also provides much higher efficacy against severe disease and hospitalizations.

Clinical trials of a combination of AstraZeneca/Sputnik Light show higher immunogenicity levels than the original AstraZeneca vaccine.

RDIF and the Ministry of Health of Argentina are co-sponsoring the first multivaccine combination trial targeting 2,800 subjects (560 in each of the 5 provinces: City and Province of Buenos Aires, as well as Córdoba, La Rioja and San Luis).

Interim results of the study in Argentina on heterologous regimens combining Sputnik Light and vaccines produced by AstraZeneca, Sinopharm, Moderna and Cansino from over 1,000 volunteers show Sputnik Light is an effective universal booster for these vaccines. Each “vaccine cocktail” combination with Sputnik Light provided higher antibody titer on 14th day after administering the second dose as compared to original homogenous (same vaccine as first and second dose) regimens of each of the vaccines.

The data from Argentina also demonstrated high safety profile of using Sputnik Light in combinations with all other vaccines with no serious adverse events following the vaccination in any combinations.

Kirill Dmitriev, CEO of the Russian Direct Investment Fund (RDIF), said:

Russia took the lead in utilizing the vaccine cocktail approach (with heterologous boosting at the core of the Sputnik V vaccine) and was also the first to offer vaccine partnerships to other producers. Clinical trials of combinations of the first component of Sputnik V (the one-shot Sputnik Light vaccine) with other vaccines are successfully ongoing around the world. Sputnik Light demonstrates strong safety and immunogenicity results in joint studies making it a universal booster and one of the best solutions for revaccinating individuals, who had been previously administered other vaccine.”

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Russian Direct Investment Fund (RDIF) is Russia’s sovereign wealth fund established in 2011 to make equity co-investments, primarily in Russia, alongside reputable international financial and strategic investors. RDIF acts as a catalyst for direct investment in the Russian economy. RDIF’s management company is based in Moscow. Currently, RDIF has experience of the successful joint implementation of more than 80 projects with foreign partners totaling RUB 2.1tn and covering 95% of the regions of the Russian Federation. RDIF portfolio companies employ more than 1 mn people and generate revenues which equate to more than 6% of Russia’s GDP. RDIF has established joint strategic partnerships with leading international co-investors from more than 18 countries that total more than $40 bn. Further information can be found at rdif.ru

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7 Reasons Why You Should Purchase Italian Furniture

7 Reasons Why You Should Purchase Italian Furniture

Very often we see people speaking ever so highly of the Italian furniture they own, while we see others gushing over Italian furniture and expressing their deep desire to own at least one such piece of furniture. Italian design and decor are widely hailed across the world for their strong emphasis on quality and simple shapes that combine both tradition and modernity through the finest craftsmanship.

The way a person decorates their home is a reflection of their personal style and identity. Needless to say, tastes and preferences vary wildly, especially when it comes to items of furniture with regard to their size, shape, texture, and color.  However, regardless of the specific kind of design a person likes, Italian furniture is a dominant player in the furniture and home design industry.

For several centuries, Italy has been considered to be a hub for culture, literature, and the arts as well as architecture and design. Italian style interior design has been the preferred choice for an ever-increasing number of people, and this is not just a recent trend. Italy is a country that is synonymous with class, sophistication, and exceptionally high quality, and this shows in the sheer popularity of Italian furniture today. Italian sofa manufacturers take great pride in the quality and design of their sofa sets, and one need not look far to see that even the most discerning customers are duly pleased with Italian furniture.

So what is it that makes Italian furniture so popular? Let’s take a closer look!

Timeless charm and appeal

Italian sofas, chairs, tables, and other pieces of furniture have a charm that is impossible to compete with, leave alone outdo. Not only are Italian furniture pieces renowned across the world for their quality and appeal, but they are also items whose aesthetic value appreciates over time. Italian furniture has an inimitably characteristic beauty and these furniture pieces only tend to look even better as the years’ pass. The fact that only the best quality materials are used for their manufacture is what makes Italian furniture so sought after.

Strong and durable

While many prospective customers will tend to get deterred or even discouraged by the fact that Italian furniture costs a fair amount of money, these furniture pieces are made with the best quality materials and are guaranteed to last for decades if not centuries. That being said, purchasing Italian furniture should be best viewed as an investment and not just an expenditure, as the elegance, durability, and comfort that these furniture pieces will offer you are their own reward.

Unbeatable quality and elegance

Italian artisans and craftsmen are famous across the world for their dedication, patience, and attention to detail. It goes without saying that Italian products, in general, are synonymous with high quality, and one only needs to look at history to see how true this is. Since time immemorial, Italian manufactures have strived for excellence and have always made sure that the products they make are nothing short of the best. Therefore, Italian furniture is a symbol of Italian perfection, sophistication, and class.

Exquisitely comfortable

The very purpose of furniture pieces such as sofas, chairs, and couches is to provide comfort to people. Italian furniture will not just provide unmatched comfort but will also give any person the feeling of being in exquisite and opulent surroundings. There is no doubt that a handcrafted piece of Italian furniture will convey a feeling of elegance and sophistication.

Wide variety of furniture designs

Many people are under the wrong impression that Italian furniture is available only in very specific parts of the world and that they are few in number. The good news is that this is not true. Artyz offers you a wide assortment of Italian furniture, and you are sure to find something that perfectly suits the design and aesthetics of your home. Not only will you be able to choose from sofas, ottomans, tables, beds, tables, and much more, you will also have the choice of selecting from a wide variety of designs. Given the fact that a lot of hard work and craftsmanship goes into making Italian furniture, you can make your living space truly unique by purchasing one or more exquisite furniture pieces.

High caliber craftsmanship

Italy is a world leader in manufacturing for a number of reasons. To begin with, only the highest quality of materials are used, and this, coupled with the unique and unparalleled skill sets that Italian artisans have, you can be assured of nothing less than the best. Italy has long been hailed for its contributions to several fields of the arts, such as painting, sculpture, music as well as design. That being said, painstaking hard work, unbridled dedication, and sharp attention to detail have made Italian craftsmanship an ideal in and of itself.

Novelty and inimitability

Unlike cheaper, mass-produced furniture that is readily available and most often delivered in a cardboard box, Italian furniture pieces are meticulously handcrafted and made with immense dedication and focus on the details. Italian furniture is very eye-catching and will without a doubt convey a sense of luxury and opulence to both residents and guests alike. Such furniture pieces will have a direct effect on the mindset and mood of residents as they will notice how the furniture pieces enhance and enrich the home.

Before you rush off to purchase Italian furniture pieces for your home, do check out Artyz. Artyz is a renowned furniture showroom in Kolkata that offers you a vast range of furniture choices that can suit the requirements of any living space and can accommodate any budget. As a leading furniture showroom, the focus remains entirely on providing top-quality furniture at affordable and reasonable prices. Simply take your pick from the diverse furniture selection and let Artyz handle the rest. By having Italian furniture in your home, you will be able to liven up your living space in unimaginable ways. The sheer elegance of Italian furniture is what creates a statement like no other style.

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Inspiring Journey of Rajasthan’s Deependra Singh Shekhawat From Monthly Salaries to Founder of Fifteen Crore Turnovers Company

Inspiring Journey of Rajasthan’s Deependra Singh Shekhawat From Monthly Salaries to Founder of Fifteen Crore Turnovers Company

Guy Kawasaki has rightly said that pursuing your passions makes you more interesting, and interesting people are enchanting. Passion is an underrated term as people believe more in hard work and dedication. We often forget that passion is what guides us to success. Deependra Singh Shekhawat is one of the few who proved that hurdles are hidden opportunities, and when utilized appropriately, they will lead you to victory.

Deependra Singh Shekhawat, being the son of a farmer, has the background of a middle-class family. He belongs to a small village of Udaipurwati, district Jhunjhunu of Rajasthan. However, his status never deterred him from dreaming. Dreams full of his passion gave him the strength to fight the battles in his life. After graduation, he initially started from a regular job. However, he was not content with his occupation. He sensed stagnancy in his career. Soon, he started thinking and strategizing about business. This thought process led him to join a renewable energy company, Adani Renewable Energy, to learn about business as the next step in his professional journey. From then on, there was no stopping him; he was on a roll. In 2015, he established Vertex Solution Company and became one of the top vendors of Adani Solar Energy. He went the extra mile by working with India’s well-known renewable energy organizations as Avada Sola, Tata Solar, O2 Power, and many more.

Deependra says that his passion for renewable energy spawns from the fact that renewable energy is one of the significant contributors to boosting the country’s economy and generating jobs. He further adds that adopting renewable sources of energy is a healthier option. He claims it is high time we start living peacefully with nature for the sanity of itself and humankind. Additionally, he has provided with job opportunities for the youth of his village Sarai and has become the Youth icon of Rajasthan. Despite belonging to a middle-class family, he left no stones unturned to achieve success and rose from the bottom of the pit to flying like an eagle. From having big dreams to making others’ dreams come true, he has come a long way.

His journey is inspiring hundreds and thousands of youngsters of middle-class families throughout the country. People are burning with passion after witnessing the change in his life. His life journey is constantly changing the lives of many for the best. He is igniting the fire of eagerness for victory in them.

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