The Proteas will bat first in the decisive fifth and final T20I against the West Indies at the National Cricket Stadium in St George's on Saturday.
The five-match T20 series is levelled at 2-2 after the hosts came back with a stellar all-round performance in Thursday's 21-run victory in the fourth T20I.
South Africa made two changes as Wiaan Mulder comes in for Reeza Hendricks and Bjorn Fortuin replaces Anrich Nortje.
Cricket South Africa revealed on Saturday that Nortje will miss the final T20 as "a precautionary measure" after the fast bowler was struck on his knee in Thursday's fourth T20.
Meanwhile, the West Indies made the one change with Akeal Hosein making his T20 debut. Fabian Allen, who is suffering from a shoulder injury, is out.
Play gets underway at 20:00 SA time.
Teams:
West Indies
Kieron Pollard (captain), Lendl Simmons, Evin Lewis, Chris Gayle, Shimron Hetmyer, Nicholas Pooran (wicketkeeper), Dwayne Bravo, Akeal Hosein, Andre Russell, Fidel Edwards, Obed McCoy
South Africa
Temba Bavuma (captain), Quinton de Kock (wicketkeeper), Rassie van der Dussen, Aiden Markram, David Miller, George Linde, Wiaan Mulder, Kagiso Rabada, Lungi Ngidi, Tabraiz Shamsi, Bjorn Fortuin