Tuesday, June 15, 2021 -- Joseph A. Baur, PhD., will present the latest research on the topic SLC25A51 controls mitochondrial NAD levels at the worlds' largest annual Aging Research and Drug Discovery conference (8th ARDD). Dr. Joseph Baur is the Associate Professor of Physiology at the University of Pennsylvania.
Joseph Baur earned his Ph.D. from the University of Texas Southwestern Medical Center in Dallas, Texas, where he studied mechanisms that limit the lifespan of cultured human cells under Drs. Jerry Shay and Woody Wright. He then moved to Harvard Medical School where he trained as a postdoctoral fellow with Dr. David Sinclair. There he developed a strong interest in the regulation of aging and metabolism by sirtuins, a conserved class of enzymes that require nicotinamide adenine dinucleotide (NAD) as a co-substrate. His lab currently studies metabolic and signaling pathways by which nutrient intake can influence longevity, with a particular emphasis on NAD and mTOR.
"Nicotinamide adenine dinucleotide is essential for mitochondrial function, but how this cofactor gets inside the organelles has not been known. Recently, we and others identified SLC25A51 as a mitochondrial transporter that is essential for importing NAD to support mitochondrial respiration." said Joseph A.Baur, PhD, Associate Professor at the University of Pennsylvania.