Researchers from Trinity College Dublin have developed a novel set of tools for designing vitamin D clinical trials that capture large seasonal and population-wide differences in vitamin D status, typically seen in individuals. Their study published in the journal Scientific Reports (today, Monday 31st May 2021) provides a framework for clinical trials to establish whether vitamin D supplementation is effective against a given disease.
The study also reveals that many trials which failed to find any association between vitamin D and disease prevention may have been underpowered or conducted without enough subjects to detect a benefit of vitamin D.