Los Angeles, USA, May 24, 2021 (GLOBE NEWSWIRE) -- Acute Bacterial Skin and Skin Structure Infections Pipeline Featuring Plethora of Emerging Drugs, Key Companies
Ceftobiprole Medocaril under Phase III trials is expected to turn out to be the most effective treatment of Acute Bacterial Skin and Skin Structure Infections.
DelveInsight’s ‘Acute Bacterial Skin and Skin Structure Infections (ABSSSI) Pipeline Insights’ report offers a detailed picture of the ABSSSI emerging therapies expected to enter the Acute Bacterial Skin and Skin Structure Infections market along with detailed coverage of the pipeline therapies under development in pre-clinical as well as clinical stages of development, partnerships taking place in the domain, recent happenings in space and growth prospects across the Diabetes domain.
Some of the key highlights of the ABSSSI Pipeline report:
- Acute Bacterial Skin and Skin Structure Infections Drug Pipeline report offer a comprehensive analysis of 15+ key players and 15+ key therapies.
- ABSSSI pipeline comprises TNP-2092 (TenNor Therapeutics), TXA709 (Taxis Pharmaceuticals), Afabicin (Debiopharm Group), Ceftobiprole Medocaril (Basilea Pharmaceutica), Brilacidin (Innovation Pharmaceuticals), Cannabidiol (Botanix Pharmaceuticals), and several others expected to get launched in the next decade.
- Out of all the emerging therapies, Ceftobiprole Medocaril the prodrug of the active moiety ceftobiprole, a cephalosporin antibiotic for intravenous administration with rapid bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria being investigated in Phase III clinical trial will turn out to be the most effective treatment of the treatment of Acute Bacterial Skin and Skin Structure Infections.
- Afabicin (Debio 1450), is a new antibiotic being developed by Debiopharm benefiting from both oral and IV formulations. It is a highly potent, staphylococcus-selective antibiotic with a low propensity to the emergence of resistance. This first-in-class FabI inhibitor retains its activity on staphylococci strains resistant to antibiotics currently in clinical use including beta-lactams, vancomycin, daptomycin or linezolid. The therapeutic candidate is set to be evaluated in bone and joint infections caused by staphylococci. The drug has completed a large Phase II study for Acute Bacterial Skin and Skin Structure Infections treatment.
- TXA709 targets ABSSSI caused by Staphylococcus aureus, including methicillin-resistant strains. The drug has received a Qualified Infectious Disease Product (QIDP) designation from the U.S. Food and Drug Administration. TXA709 is a prodrug, a biologically inactive compound that can be metabolized in the body to produce a drug, TXA707, a derivative of benzoic acid that disrupts the form and function of the bacterial protein FtsZ, which plays an essential role in bacterial cell division.
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Acute Bacterial Skin and Skin Structure Infection is a bacterial infection of the skin and associated tissues. The FDA defines skin and skin structure infections as an acute bacterial skin and skin structure infection or ABSSSI if the infection is accompanied by redness, edema, and/or induration of a minimum surface area of 75 cm2, accompanied by lymph node enlargement or systemic symptoms such as fever ≥38°C (100.4°F).
Some of the most common bacterial pathogens that cause Acute Bacterial Skin and Skin Structure Infections are Streptococcus pyogenes and Staphylococcus aureus, including methicillin-resistant S.aureus. Less common causes include other Streptococcus species, Enterococcus faecalis, or Gram Negative bacteria.
The severity of Acute Bacterial Skin and Skin Structure Infections has led to an increasing emphasis on the identification of novel strategies to treat this disease.
For more information on emerging drugs, visit Acute Bacterial Skin and Skin Structure Infections Pipeline Analysis
ABSSSI Pipeline Drugs
| Drug | Company | Clinical Phase | MoA | RoA |
| Ceftobiprole medocaril | Basilea Pharmaceutica | III | Cell wall inhibitors; Peptidyl Transferase inhibitors | Intravenous |
| TNP-2092 | TenNor Therapeutics | II | DNA gyrase inhibitors; DNA topoisomerase inhibitors; DNA-directed RNA polymerase inhibitors; RNA synthesis inhibitors | Intravenous |
| Brilacidin | Innovation Pharmaceuticals | II | Cell membrane permeability enhancers; Cell membrane structure modulators; Immunomodulators; Type 4 cyclic nucleotide phosphodiesterase inhibitors; Virus internalisation inhibitors | Intravenous |
| Afabicin | Debiopharm Group | II | Enoyl-ACP reductase inhibitors | Intravenous and Oral |
| Contezolid acefosamil | MicuRx Pharmaceuticals | II | Protein synthesis inhibitors | Intravenous and Oral |
| TXA709 | Taxis Pharmaceuticals | I | Bacterial FtsZ protein inhibitors | NA |
| Cannabidiol | Botanix pharmaceuticals | Preclinical | Antioxidants; Cannabinoid receptor CB1 inverse agonists; Cannabinoid receptor CB2 inverse agonists; Serotonin 1 receptor modulators; Transient receptor potential channel modulators | NA |
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Acute Bacterial Skin and Skin Structure Infections Drugs and Therapeutic Assessment
The ABSSSI Pipeline report presents comprehensive insights into active ABSSSI pipeline assets segmented by Stage, ABSSSI Product Type, Route of Administration, Molecule Type, Target, and Indications of various drugs.
By Product Type
- Mono
- Combination
By Stage
- Discovery
- Pre-clinical
- IND
- Phase I
- Phase II
- Phase III
- Pre-registration
By Molecule Type
- Small Molecule
- Gene Therapy
- Stem Cell Therapy
By Route of Administration
- Intravenous
- Intramuscular
- Oral
- Subcutaneous
By Mechanism of Action
- Cell wall inhibitors
- Cell membrane permeability enhancers
- Enoyl-ACP reductase inhibitors
- DNA gyrase inhibitors
- Bacterial FtsZ protein inhibitors
- Cannabinoid receptor CB1 inverse agonists
By Targets
- Protease
- Multiple Kinase
By Stage and Route of Administration
By Stage and Product Type
Scope of the Report
Coverage: Global
Key Players: Basilea Pharmaceutica, TenNor Therapeutics, Innovation Pharmaceuticals, Debiopharm Group, MicuRx Pharmaceuticals, Taxis Pharmaceuticals, Botanix pharmaceuticals, Motif Bio, KBP Biosciences, Atox Bio and others.
Key ABSSSI Pipeline Therapies: Ceftobiprole medocaril, TNP-2092, Brilacidin, Afabicin, Contezolid acefosamil, TXA709, Cannabidiol, KBP-7072, Nemonoxacin, AB-103 and others.
Table of Contents
| 1 | Introduction |
| 2 | Executive Summary |
| 3 | Acute Bacterial Skin and Skin Structure Infections Overview |
| 4 | ABSSSI Pipeline Therapeutics |
| 5 | Acute Bacterial Skin and Skin Structure Infections Pipeline Therapeutic Assessment |
| 6 | Acute Bacterial Skin and Skin Structure Infections – DelveInsight’s Analytical Perspective |
| 7 | In-depth Commercial ABSSSI Pipeline Assessment |
| 8 | Acute Bacterial Skin and Skin Structure Infections Collaboration Deals |
| 9 | Late Stage ABSSSI Pipeline Products (Phase III and Preregistration) |
| 10 | Mid-Stage Acute Bacterial Skin and Skin Structure Infections Pipeline Products (Phase II) |
| 11 | Pre-clinical and Discovery Stage ABSSSI Pipeline Products |
| 12 | Inactive Acute Bacterial Skin and Skin Structure Infections Pipeline Products |
| 13 | Acute Bacterial Skin and Skin Structure Infections Key Companies |
| 14 | ABSSSI Key Products |
| 15 | Acute Bacterial Skin and Skin Structure Infections Unmet Needs |
| 16 | Acute Bacterial Skin and Skin Structure Infections Market Drivers and Barriers |
| 17 | ABSSSI Future Perspectives and Conclusion |
| 18 | Acute Bacterial Skin and Skin Structure Infections Pipeline Analyst Views |
| 20 | Appendix |
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