https://www.spandidos-publications.c...?text=abstract
August 25, 2017 It is well known that Panax ginseng (PG) has various pharmacological effects such as anti-aging and anti-inflammation. In a previous study, the authors identified that PG extract induced hair growth by means of a mechanism similar to that of minoxidil. In the present study, the inhibitory effect of PG extract on Dickkopf-1 (DKK-1)-induced catagen-like changes in hair follicles (HFs) was investigated in addition to the underlying mechanism of action. The effects of PG extract on cell proliferation, anti-apoptotic effect, and hair growth were observed using cultured outer root sheath (ORS) keratinocytes and human HFs with or without DKK-1 treatment. The PG extract significantly stimulated proliferation and inhibited apoptosis, respectively, in ORS keratinocytes. PG extract treatment affected the expression of apoptosis-related genes Bcl-2 and Bax. DKK-1 inhibited hair growth, and PG extract dramatically reversed the effect of DKK-1 on ex vivo human hair organ culture. PG extract antagonizes DKK-1-induced catagen-like changes, in part, through the regulation of apoptosis-related gene expression in HFs. These findings suggested that PG extract may reduce hair loss despite the presence of DKK-1, a strong catagen inducer via apoptosis.
|
|
Results 1 to 8 of 8
Thread: Ginseng for hair loss?
-
Today, 06:40 AM #1Registered User
- Join Date: Feb 2006
- Posts: 7,243
- Rep Power: 20788
Ginseng for hair loss?
- root console
-
Today, 06:55 AM #2gif me so i can gif you
- Join Date: Nov 2015
- Posts: 22,184
- Rep Power: 98381
iam all in
but ginseng
do cause the
accelerated energy rush and crash the chit out of me...srs
I lost My old Signature, please help me find the rest of the Verses.
I used to postpone fisting session, now fisting is part of my daily routine.
All gifs made in Misc thread:
https://forum.bodybuilding.com/showthread.php?t=178547811
-
Today, 06:58 AM #3
Can you outline the mechanism of androgenic hair loss?
AR with relatively high affinity for DHT leading to downstream death of hair follicles.
Does this stop an intermediate step?
Does it simply improve the appearance during loss, like rogaine?
Does it systemically disturb androgen signalling?
-
Today, 07:01 AM #4Registered User
- Join Date: Oct 2007
- Location: United Kingdom (Great Britain)
- Age: 33
- Posts: 1,493
- Rep Power: 9373
Doesn't Monster energy drink have ginseng in it?
Balding tradies rejoice!The more i learn about people, the more i like my dog.
-
Today, 07:19 AM #5Registered User
- Join Date: Feb 2006
- Posts: 7,243
- Rep Power: 20788
DHT activates DKK-1, which strongly inhibits hair growth (which looks to be driven by Wnt/B-catenin).Originally Posted by merb0
Dickkopf-1 (DKK-1), which is a potent antagonist of the Wnt/β-catenin signaling pathway, is inducible by dihydrotestosterone (DHT) and promotes catagen progression and the apoptotic cell death of HFs (11). Kwack et al (12,13) demonstrated that DKK-1 is secreted from hDPCs in response to DHT and that it promotes the regression of HFs by blocking Wnt/β-catenin signaling and by inhibiting the growth of ORS keratinocytes and triggering apoptotic cell death.
Not sure on the systematic effects. Ginseng taken normally is systematic. This was a "ex vivo" study or done outside the body in a scientific environment. Not sure if the effects translate. Ginseng does have quite a few systematic effects that are positive as far as cancer and general health. I don't know if this would be applied topically, my guess is yes. They compared it to minoxidil (aka rogaine) in how it works so that is more towards topical I'm thinking.
-
Today, 07:21 AM #6Never accept defeat!
- Join Date: Aug 2018
- Posts: 16,073
- Rep Power: 209983
Reminds me of this guy on youtube who used natural products against his hairloss. Dude was like a norwood 100.
In the end there's finasteride and hair transplants. If the reaper is coming, there is no alternative.Cobra Kai never dies!
-
Today, 07:30 AM #7
Does min do the same thing?
If so, why do people bother with 5AR at all? Incomplete inhibition of the pathways?
A drug more tailored to this mechanism makes more sense, though ginseng seems well-tolerated.
-
Today, 07:38 AM #8Registered User
- Join Date: Feb 2006
- Posts: 7,243
- Rep Power: 20788
I'm thinking people can also try and walk back on DHT naturally. Lower bf to keep testosterone up (dht seems to come out more when fat rises), not quite as heavy of weight... 80% of 1-rep max or so to go after that slow twitch fat burning muscle type rather than glycolytic fast twitch max strength fibers.Originally Posted by backinthegymbro
Minox only works in 20-40% of people. Otherwise its great for hairOriginally Posted by merb0
Last edited by rootcon; Today at 07:44 AM.
Bookmarks