Producer and composer Lebo M and Angela Ngani-Casara will go their separate ways after another attempt to build a family.
The couple have previously been married to one another.
"We had hoped that the third attempt would have been the final one in both our lives," said the couple in a joint statement, issued by Neo Motlhala on behalf of the Morake family.
"We have tried hard, and we are proud of our efforts. Regrettably, we simply did not connect," they concluded.
The couple recently featured in their TV reality show, Lebo M - Coming Home on Showmax, which has been nominated for a 2021 South African Film and Television Awards (SAFTA) for Best Structured Soap Reality Show.
The couple request privacy as they try to heal and navigate the new chapters of their lives.