CINCINNATI -- Shane Bieber kept up his record strikeout run, fanning 13 and pitching the Cleveland Indians past the Cincinnati Reds 6-3 on Sunday.

Bieber (2-1) become the first pitcher in big league history to begin the season with four straight starts with at least 10 strikeouts since the mound was moved to its current distance back in 1893.

The AL Cy Young Award winner has 48 strikeouts this year, matching Hall of Famer Nolan Ryan for the most through the first four starts of a season. Bieber has fanned at least eight in a 16 straight starts, one short of Randy Johnson's major league mark.

Bieber went eight innings, allowing three runs and six hits with two walks.

Emmanuel Clase struck out the side in the ninth, again hitting 100 mph with his heater.

The Indians hit three home runs, all with two outs, to salvage a win in the all-Ohio series.

Roberto Perez hit a three-run homer off Wade Miley (2-1) over the center-field wall with two on in the fourth inning for a 4-0 lead.

Jose Ramirez launched a solo drive into the upper deck in the first. Jordan Luplow had a two-run homer in the seventh.

Wade Miley (2-1) took the loss for the Reds, lasting five innings and striking out five.

Joey Votto had three hits, including a two-run double in the Reds fifth. Tyler Naquin homered off Bieber in the eighth.

Reds third baseman Mike Moustakas missed his third straight game with a non-COVID illness. Kyle Farmer started in his place. OF Shogo Akiyama (hamstring) is back with the team, but he is not expected to play until at least May.

The Associated Press contributed to this report.