Nobel Prize in Medicine: Achievements to heal and cure
2019: Undertanding how cells adapt to oxygen
William Kaelin, Peter Ratcliffe and Gregg Semenza discovered how cells sense and adapt to the availability of oxygen. When oxygen level change, cells undergo shifts in gene expression. Responses include cell metabolism, tissue remodeling and heart rate. It plays a role at high altitudes and has medical implications from exercising to pregnancy, altitude sickness and wound healing.
Author: Brigitte Osterath