Pfizer-BioNTech Shot Stops Covid Spread, Israeli Study Shows

(Bloomberg) --

The Pfizer Inc. and BioNTech SE Covid-19 vaccine appeared to stop the vast majority of recipients in Israel becoming infected, providing the first real-world indication that the immunization will curb transmission of the coronavirus.

The vaccine, which was rolled out in a national immunization program that began Dec. 20, was 89.4% effective at preventing laboratory-confirmed infections, according to a copy of a draft publication that was posted on Twitter and confirmed by a person familiar with the work. The companies and Israel’s Health Ministry worked together on the preliminary observational analysis, which has not yet been peer-reviewed.

The results, also reported in Der Spiegel, are the latest in a series of positive data to emerge out of Israel, which has given more Covid vaccines per capita than anywhere else in the world. Nearly half of the population has had at least one dose of vaccine. Separately, Israeli authorities on Saturday said the Pfizer-BioNTech shot was 99% effective at preventing deaths from the virus.

More Than 202 Million Shots Given: Covid-19 Tracker

The early results on lab-confirmed infections are important because they indicate the vaccine may also prevent asymptomatic carriers from spreading the virus that causes Covid-19. That’s not been clear because the clinical trials that tested the safety and efficacy of vaccines focused on the ability to stop symptomatic infections.

Herd Immunity

“These are the data we need to see to estimate the potential for achieving herd immunity with vaccines,” said Raina MacIntyre, professor of biosecurity at the University of New South Wales in Sydney, in an email Monday. “However, we do need to be able to see the data published in a peer-reviewed journal and to be able to scrutinize the data in detail.”

Pfizer and BioNTech said they are working on a real-world analysis of data from Israel, which will be shared as soon as it’s complete. Spokespeople declined to comment on unpublished data.

Four-fifths of the virus cases in Israel during the time period of the study, from Jan. 17 to Feb. 6, were the more transmissible strain first identified in the U.K. Israel’s vaccination drive began just before the so-called B.1.1.7 variant emerged, fueling infections and leading to a third lockdown on Jan. 8.

Through Feb. 6, about 27% of people aged 15 and older in Israel were fully vaccinated, with the Pfizer-BioNTech shot the only vaccine available in the country at the time. People were considered fully vaccinated and included in the analysis if the data collected were more than seven days after they received their second dose.

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