Former England Under-20 international Cameron Redpath will make his Scotland debut in their Six Nations opener at Twickenham on Saturday.
The Bath centre, the son of former Scotland scrum-half Bryan Redpath, starts in the Calcutta Cup clash just weeks after confirming his allegiance to Scotland.
He will also be going up against fellow Bath centre and close friend Ollie Lawrence, who has been selected in England's midfield.
Elsewhere in Scotland's back division, wing Sean Maitland and fit-again fly-half Finn Russell have been recalled, while hooker George Turner will make his Six Nations debut.
Saturday's match marks the 150th anniversary of the first meeting between England and Scotland -- rugby union's oldest international fixture.
Teams:
England
15 Elliot Daly, 14 Anthony Watson, 13 Henry Slade, 12 Ollie Lawrence, 11 Jonny May, 10 Owen Farrell (captain), 9 Ben Youngs, 8 Billy Vunipola, 7 Tom Curry, 6 Mark Wilson, 5 Jonny Hill, 4 Maro Itoje, 3 Will Stuart, 2 Jamie George, 1 Ellis Genge
Substitutes: 16 Luke Cowan-Dickie, 17 Beno Obano, 18 Harry Williams, 19 Courtney Lawes, 20 Ben Earl, 21 Dan Robson, 22 George Ford, 23 Max Malins
Scotland
15 Stuart Hogg (captain), 14 Sean Maitland, 13 Chris Harris, 12 Cameron Redpath, 11 Duhan van der Merwe, 10 Finn Russell, 9 Ali Price, 8 Matt Fagerson, 7 Hamish Watson, 6 Jamie Ritchi, 5 Jonny Gray, 4 Scott Cummings, 3 Zander Fagerson, 2 George Turner, 1 Rory Sutherland