RIST Popular Talk -47
Enhancement of photoacoustic (PA) signal strength
Date - 24th December, 2020

INVITATION

You are cordially invited to attend a talk on the topic:
A photothermal-based (non-invasive) technique for enhancement of photoacoustic (PA) signal strength with continuous wave (CW) optical pre-illumination

Jointly organized by
Department of Physics, M.U. and
Research Institute of Science and Technology (RIST), Imphal.

VENUE and DATE
Department of Physics, M.U.,
on Thursday, 24th December, 2020 at 2.00 pm

By: Dr. M Suheshkumar Singh,
Assistant Professor
School of Physics, IISER, Thiruvananthapuram (IISER-TVM)

Abstract: Photoacoustic imaging (PAI) stands as a promising technology for non-destructive recovery of vital patho-physiological parameters (functional, structural, hemo-dynamics, mechanical, and molecular distribution) of biological tissues with microscopic resolution at an unprecedented penetration depth (~ cms).

Enhancement of the achievable signal strength in photoacoustic (PA) imaging - that enables not only to improve obtainable imaging depth but also to increase accuracy in quantitative measurement of physiological parameters by improving signal-to-noise-ratio (SNR) - is becoming one of the most focusing areas of research study since the past few years.

In this talk, study of a non-invasive technique for enhancing strength of PA-signal will be presented. This is a photothermal-based technique in which CW-optical beam, in addition to short-pulse (~ nsec) laser beam, is employed to irradiate and thus, raise temperature of sample material selectively over a pre-specified region of interest.

Experimental results - with experiments being conducted on various samples (including tissue-mimicking Agar phantom and ex-vivo animal tissue (chicken breast)) to validate the proposed technique for clinical and/or pre-clinical applications - will be presented.

A theoretical hypothesis, along with numerical simulation studies, is presented. Results demonstrate that pre-illumination significantly enhances PA-signal strength (upto ~ 70% (methylene blue), ~ 48% (Agar phantom)), and ~ 40% (chicken tissue)).

(Prof. N. Nimai Singh)
Convener,
RIST monthly popular talk series
Head, Department of Physics
Manipur University
Canchipur – 795 003
Imphal, Manipur
Website: www.manipuruniv.ac.in