Oxford/AstraZeneca vaccine expands to GP services in UK

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PTI
January 07, 2021 / 02:18 PM IST

Britain became the first country in the world to approve the coronavirus vaccine developed by Oxford University and AstraZeneca.

Supplies of the Oxford University vaccine produced by AstraZeneca vaccine have begun expanding to General Practice (GP) led services from Thursday to make it easier to protect care home residents and other vulnerable people against COVID-19, the UK government said.

As part of a phased rollout since the jabs received regulatory approval last month, the vaccine has been trialled at selected hospitals in the country for surveillance purposes before being sent out to hundreds of community-based local vaccination services.

“The biggest vaccination programme in NHS (National Health Service) history is already off to a strong start with around 1 million people already vaccinated against coronavirus – this is a credit to our exceptional NHS staff,” said Dr Nikki Kanani, GP and NHS medical director for primary care.

“GPs, nurses, pharmacists and countless other staff and volunteers have been working around the clock to be able to launch almost 200 more sites this week. Combined with the arrival of the Oxford/AstraZeneca vaccine, we will now be able to protect many more vulnerable people against the virus and faster,” she said.

It comes as the UK remains under a strict stay-at-home lockdown as the infection rates from a new variant of coronavirus surged further, with 62,322 new cases and 1,041 deaths recorded on Wednesday.

COVID-19 Vaccine

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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UK Prime Minister Boris Johnson said it will be these vaccines that provide the "means of escape" from lockdown and has pledged daily vaccination updates starting next Monday.

Unlike the Pfizer vaccine, the first to be approved for use in the UK last year, the Oxford vaccine does not need to be stored at ultra-low temperatures and is therefore much easier to move, making it easier to use in care homes and to vaccinate the housebound.

NHS England said that hundreds of new sites are opening at hospitals and in the community this week in the new phase of the vaccination programme. This is on top of the 700 which were already open and vaccinating, with seven vaccination centres among many more sites coming online next week, along with more hospitals, GP-led services and a number of pilot pharmacy vaccine services.

“Every part of the government and the NHS are working around the clock to rapidly scale up our COVID-19 vaccination programme so we can protect those most at risk from this awful disease as quickly as possible,” said UK Health Secretary Matt Hancock.

“The Oxford/AstraZeneca vaccine can be transported easily and I’m delighted care home residents will begin receiving their first Oxford/AstraZeneca jabs this week. More than 1.3 million people have already been vaccinated in the UK, including 23 per cent -- or over 650,000 -- of the over-80s in England,” he said.

The minister said the government aims to offer vaccinations to the majority of care home residents by the end of January and all 13 million people in the top four priority cohorts of those at the highest risk of death from the virus by mid-February.

“This will ensure the most vulnerable are protected and will save tens of thousands of lives. As our vaccination programme ramps up, I urge everybody to continue following the latest restrictions to keep cases low and protect loved ones,” he said.

The NHS, which is leading the vaccination programme, said up to 100 hospital more sites are due to come online across the country, subject to final assurance checks, this week. There are also another 180 GP-led services which are also due to come online this week.

The rollout comes after the vaccine was approved for use outside of hospitals by the four Chief Medical Officers of the United Kingdom and NHS England’s Medical Director, Professor Stephen Powis. Care home residents cannot travel to hospital for a jab and Pfizer is difficult to get to hospitals so the latest decision will speed up the drive to vaccinate them.

Care home residents and staff were set as the highest priority group by the independent Joint Committee on Vaccination and Immunisation. In addition to the Oxford jab, local vaccination services are being issued with small packs of Pfizer jabs which can be used in care homes.

When the vaccine was first issued it had to be shipped in “pizza boxes” containing almost 1,000 doses, meaning that care homes could not be jabbed without wasting supplies, the NHS said.

GP services are being offered an extra 10 pound for every care home resident vaccinated in January, in a drive to get a majority vaccinated before the end of the month.

“The NHS was the first health service in the world to deliver a COVID-19 vaccination outside of the clinical trial. The NHS was also the first to deliver the Oxford AstraZeneca vaccine, jabbing Brian Pinker, 82, at Oxford University Hospital on Monday,” NHS England said.

It added that current and former NHS staff have applied to become vaccinators, with tens of thousands having already completed their online training. They will be deployed as more vaccine supplies become available.
PTI
TAGS: #coronavirus #Covid-19 #World News
first published: Jan 7, 2021 02:18 pm