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Coronavirus News LIVE Updates: No evidence vaccines won't work against new COVID-19 strains, says Centre's principal scientific adviser

Coronavirus News LIVE Updates:In a press briefing on Tuesday, Professor K Vijay Raghavan said that vaccines stimulate the immune system to produce a wide range of protective antibodies and the changes in the variants are not sufficient to make the vaccines ineffective

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Coronavirus News LIVE Updates: No evidence vaccines won't work against new COVID-19 strains, says Centre's principal scientific adviser

Representational image. PTI

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LIVE NEWS and UPDATES

Dec 29, 2020 - 17:46 (IST)

At least 19 variants of SARS-CoV-2 have evolved in India, claims study

At least 19 genetic variants of the SARS-CoV-2 in India have evolved to evade neutralising antibodies that the human immune system and one of these variants having already caused a confirmed case of reinfection in the country, said reports citing a study by the CSIR. A team from CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), New Delhi, Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC, Uttar Pradesh, and Kurnool Medical College in Andhra Pradesh identified 120 ‘immune escape variants’ in SARS-CoV-2 from across the globe, said a report by The Print. 

The paper has been uploaded in a preprint server and yet to be peer-reviewed, said a Deccan Herald report. As per the report, A variant with a mutation named N440K has been found in nearly 34 percent of the 272 SARS-CoV-2 genomes analysed from Andhra Pradesh. The variant has also been seen in Karnataka, Maharashtra and Telangana nad has caused at least one case of re-infection, reported in a Noida hospital. As per The Print, the S:N440K was found to be in 2.1 percent of the gene sequences in India.

Dec 29, 2020 - 17:28 (IST)

Genome sequencing for all COVID-19 positive flyers who arrived in India from 9 to 22 Dec

 All international passengers who arrived in India from 9 to 22 December and tested positive for COVID-19 will be subjected to genome sequencing as part of the Centre's strategy to detect the mutated coronavirus strain that has emerged in the United Kingdom recently.   Others will be followed up by the state and district surveillance officers, and will be tested as per ICMR guidelines, even if asymptomatic, between fifth and 10th day of arrival, according to the Union Health Ministry's guidance document on genomic sequencing. "All the international passengers who have arrived in India during the last 14 days (from December 9 to 22), if symptomatic and tested positive, will be subjected to genome sequencing," the document stated.

Dec 29, 2020 - 17:19 (IST)

Former Himachal Pradesh CM's wife Santosh Shailza dies of COVID-19

 
Former Himachal Pradesh chief minister Shanta Kumar's wife Santosh Shailza succumbed to coronavirus in the early hours of Tuesday, Health Minister Rajiv Saizal said. She was 83.  She was cremated as per coronavirus protocol at a crematorium in Kangra's Palampur. Shailza was undergoing treatment at Dr Rajendra Prasad Government Medical College in Kangra's Tanda. She was admitted to the facility after testing positive for COVID-19 a few days ago.  
 
PTI

Dec 29, 2020 - 16:44 (IST)

States may impose night curfew, says Centre

Restrictions, such as night curfews, may be imposed by states and UTs based on local situation says DR VK Paul. "The major population is still susceptible to COVID19 infection in this cold weather. UK variant has travelled to several other countries and also to India, this variant may have its own run and we've to very careful. One can't be careless:, he cautioned.

Dec 29, 2020 - 16:34 (IST)

Six cases of UK variant found in India, says Centre

Six cases of UK variant found in India, saysCentre. The virus has travelled to other countries and also to India. It is important to remember that it is easy to tackle a virus or a new strain at the beginning, before there are multiple chains of transmission.

Dec 29, 2020 - 16:25 (IST)

No evidence that vaccines will fail to protect against new virus strains

No evidence that vaccines will fail to protect against new coronavirus variants in UK and South Africa, says Principle Scientific Advisor to govt Prof K. Vijay Raghavan.  "Most vaccines do target the Spike protein, in which there are changes in the variants, but vaccines stimulate our immune system to produce a wide range of protective antibodies. The changes in the variants are not sufficient to make the vaccines ineffective, The Hindu quotes him as saying.

As per the news paper, he further says: Eight of seventeen changes in spike protein cause changes in virus. . One change (N501Y) increases affinity for the ACE2 receptor, used for viral entry into human cells. It has been linked earlier to increased infectivity and transmission in animal models. Another change (P681H) promotes entry into susceptible cells and increases transmission in animal models of infection. The South Africa also shares the N501Y mutation with the UK variants, in addition to other distinct changes."

The virus strain in UK is more transmissible and this also reflected in the increase in positivity rate in the UK, he said adding that there is no evidence that it increases severity of disease. "We must take extraordinary precautions  to prevent these kinds of variants from dominating populations," Raghavan adds.

Dec 29, 2020 - 16:17 (IST)

Five states and UTs account for 60% of active cases

Five states and UTs account for 60% of active cases, with Kerala accounting for over 23% of the active cases, says health ministry.

Dec 29, 2020 - 16:15 (IST)

52% cases found in 18-44 age group, says health ministry

63 percent of total coronavirus cases in the country were amongst men while 37 percent were among women. Giving the age wise distribution, he said 39 recent of the total cases were in the 26-44 age group, 52% cases between 18-44 age group but only 11% deaths were reported from this age group.

Daily deaths are also less than 300 after 6 months,says Bhushan, adding that 55% deaths are found to have occured in 60 years and above age group and 70 percent of the deaths have occurred among males.

Dec 29, 2020 - 16:10 (IST)

INSACOG consortium established for genome sequencing of SARS-CoV-2

Active cases in country fall below 2.70 lakh after six lakh.Cumulative positivity rate is 6.02% and last week's positivity rate is only 2.25%. INSACOG consortium has been established consisting of 10 govt labs for genome sequencing. These labs belong to ICMR, DBT, CSIR and health ministry, informed Health SEcretary Rajesh Bhushan They have been doing genomic sequencing of SarsCoV-2 since last 11 months, roughly 5,000 genome sequences done across these labs before UK strain

Dec 29, 2020 - 15:59 (IST)

Health ministry to conduct COVID-19 review meet

The Union health minsitry will be holding a briefing on the COVID-19 situation in the country at 4 pm on Tuesday. 

 

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News LATEST Updates: "There is no evidence that current vaccines will fail to protect against variants reported from UK or South Africa," said Prof K Vijay Raghavan, principal scientific advisor to the Centre.

The vaccines stimulate the immune system to produce a wide range of protective antibodies and the changes in the variants are not sufficient to make the vaccines ineffective, he explained.

Union health secretary Rajesh Bhushan said 63 percent of total cases in the country were amongst men while 37 percent were among women. Giving the age wise distribution, he said 39 percent of the total cases were in the 26-44 age group, 52percent cases between 18-44 age group but only 11percent deaths were reported from this age group.

Daily deaths are also less than 300 after six months, says the health secretary, adding that 55 percent deaths are found to have occured in 60 years and above age group and 70 percent of the deaths have occurred among males.

In a press briefing, health secretary Rajesh Bhushan informed that cumulative positivity rate is 6.02 percent and daily new cases are below 17,000 after six months.

The dry run for vaccination successfully conducted in Assam, Andhra Pradesh, Punjab, and Gujarat on 28 and 29 December 2020, said the Union health ministry on Tuesday.

India had suspended passenger flights to and from the UK between 23 December and 31 December (both days included), after a growing list of countries like Canada, Germany, France, Netherlands, Belgium, Denmark and Italy did the same due to a more infectious variant there.

Gujarat is one of the four states chosen by the Central government to conduct the mock vaccination drive.

India’s tally rose to 1,02,24,303 after 16,432 new cases emerged in 24 hours. This is the lowest daily spike in infections since 24 June. Of the 252 new fatalities, 50 were reported in Maharashtra, 27 in West Bengal, 26 in Chhattisgarh and 21 from Delhi.

Six persons who returned to India from the United Kingdom have tested positive for the new UK variant genome of SARS-CoV2, the Union Health Ministry said on Tuesday.

India recorded 16,432 fresh cases in the past 24 hours, taking the country's overall count to 1,02,24,303 on Tuesday.

Of the total cases, active infections further dropped to 2.68 lakh while recoveries surpassed 98 lakh after more than 24,900 patients were cured of the novel , said the health ministry on Tuesday.

Ten regional laboratories have been identified by the Centre where states will send five percent of their positive samples for genome sequencing to detect the new variant that has emerged in the United Kingdom recently.

The health ministry has also established the Indian SARS-CoV-2 Genomics Consortium (INSACOG) for laboratory and epidemiological surveillance and expand whole genome sequencing of the in the country, aiding in the understanding of how the virus spreads and evolves.

The emergence of the new strain in the UK has required India to increase viral genomic surveillance in order to understand the spread of the virus in a rapid and robust manner.

"The 10 regional genome sequencing laboratories spread across the country will cater to the nearest states, which will send five percent of the positive samples to these labs for genome sequencing," stated the Union Health Ministry's guidance document on genomic sequencing released on Monday.

The viral genome sequencing data generated will be analysed by the respective centres and sent to the National Centre for Disease Control (NCDC), Delhi, for collation and integration.

The 10 labs are DBT-National Institute of Biomedical Genomics, Kalyani (near Kolkata), DBT-Institute of Life Sciences in Bhubhaneshwar, ICMR-National Institute of Virology and DBT-National Centre for Cell Science in Pune, CSIR-Centre for Cellular and Molecular Biology and DBT-Centre for DNA Fingerprinting and Diagnostics, Hyderabad, DBT InSTEM/NCBS, Bengaluru, National Institute of Mental Health and Neuro Sciences Hospital in Bengaluru, CSIR-Institute of Genomics and Integrative Biology and NCDC in Delhi.

The Central Surveillance Unit under the Integrated Disease Surveillance Programme (IDSP) at the National Centre for Disease Control (NCDC) regularly collects data in a decentralized manner from various states. Such data will be used for selecting the representative positive samples from various regions for genome sequencing, the document stated.

Further, the data from the genome sequencing laboratories will be analysed as per the field data trends to study linkages, if any, between the genomic variants and epidemiological trends.

"This will help in understanding super-spreader events and outbreaks, and strengthen public health interventions across the country to help in breaking the chains of transmission. Linking this data with the IDSP data and patient's symptoms will allow us to better understand the viral infection dynamics, morbidity and mortality trends," the ministry said.

According to the action plan, in case the UK variant or any other mutated strain of the is detected in any sample, it will be sent to any of the two notified COVID Virus Repositories at RCB Faridabad or NIV, Pune, for its isolation and further culturing.

This can then be shared as per notified guidelines for development of assays, which will help in validation of diagnostics and also testing of the vaccines under development.

The SOPs, which have been developed for the SARS-CoV-2 Genome Sequencing sample collection, deposit and sharing in May, 2020 will be adopted, the document stated.

An NCDC nodal unit will maintain a database of all samples of the new variants. The data will be epidemiologically analysed, interpreted and shared with states for investigation, contact tracing and planning response strategies.

The Central Surveillance Unit (CSU) will monitor the trends in various states with regard to identifying super-spreader events and outbreaks. A representative sample of all positive cases in such events will be sent to the designated lab for genome sequencing.

The objectives of the Indian SARS-CoV-2 Genomics Consortium (INSACOG) is to monitor the genomic variations in the on a regular basis through a multi-laboratory network. This vital research consortium will also assist in developing potential vaccines in the future.

In the present scenario, it will be pertinent that a genome surveillance is established to ascertain the current status of new variant of SARS-CoV-2 in the country and to establish a sentinel surveillance for early detection of genomic variants with public health implication besides determining the genomic variants in the unusual events, the ministry said.

Updated Date: December 29, 2020 17:28:49 IST

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