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COVID-19 vaccine | Covaxin can generate antibodies that may persist for 6-12 months, says study

Bharat Biotech's COVID-19 vaccine, Covaxin, has been developed in collaboration with the Indian Council of Medical Research (ICMR) - National Institute of Virology (NIV).

December 23, 2020 / 08:19 PM IST

Bharat Biotech, which received the approval for phase III clinical trial of COVID-19 vaccine Covaxin on October 22, is aiming for June 2021 launch.

Bharat Biotech's COVID-19 vaccine, Covaxin, has showed long-term antibody and T-cell memory responses (three-months after vaccination) in phase I volunteers, and tolerable safety outcomes in the Phase II trials, a paper has said.

According to the research, Covaxin can also generate antibodies that may persist for six to 12 months.

The study, which has not been peer reviewed and the findings of which are provisional, also said during the phase II clinical trial, a total of 380 healthy children and adults were randomised to receive two vaccine formulations.

"After two doses, local and systemic adverse reactions observed in both vaccine groups were minimal, and the majority of them resolved within 24 hours of onset. No serious adverse events were reported in this study," the study said. 

COVID-19 Vaccine

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How does a vaccine work?

A vaccine works by mimicking a natural infection. A vaccine not only induces immune response to protect people from any future COVID-19 infection, but also helps quickly build herd immunity to put an end to the pandemic. Herd immunity occurs when a sufficient percentage of a population becomes immune to a disease, making the spread of disease from person to person unlikely. The good news is that SARS-CoV-2 virus has been fairly stable, which increases the viability of a vaccine.

How many types of vaccines are there?

There are broadly four types of vaccine — one, a vaccine based on the whole virus (this could be either inactivated, or an attenuated [weakened] virus vaccine); two, a non-replicating viral vector vaccine that uses a benign virus as vector that carries the antigen of SARS-CoV; three, nucleic-acid vaccines that have genetic material like DNA and RNA of antigens like spike protein given to a person, helping human cells decode genetic material and produce the vaccine; and four, protein subunit vaccine wherein the recombinant proteins of SARS-COV-2 along with an adjuvant (booster) is given as a vaccine.

What does it take to develop a vaccine of this kind?

Vaccine development is a long, complex process. Unlike drugs that are given to people with a diseased, vaccines are given to healthy people and also vulnerable sections such as children, pregnant women and the elderly. So rigorous tests are compulsory. History says that the fastest time it took to develop a vaccine is five years, but it usually takes double or sometimes triple that time.

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Covaxin has been evaluated in approximately 1,000 subjects in Phase I and Phase II clinical trials, with promising safety and immunogenicity results, Bharat Biotech had earlier said in a statement.

The indigenously developed COVID-19 vaccine has been developed in collaboration with the Indian Council of Medical Research (ICMR) - National Institute of Virology (NIV).

Read: AstraZeneca says its vaccine should be effective against new coronavirus variant

The company had on December 22 announced recruitment of 13,000 volunteers and continued progress towards achieving the goal of 26,000 participants for the Phase III clinical trials of the vaccine.

The company had started the phase III clinical trials in mid-November.
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