An estimated 521,300 people in England had COVID-19 from 22 to 28 November - a fall from 633,000 the week before.
The Office for National Statistics says this means approximately one in 105 people in England had coronavirus over the period - an improvement from the one in 85 seen seven days earlier.
The newest data also shows that the percentage of people testing positive has decreased in all regions except the North East.
Infection rates were highest in the North East, the North West and Yorkshire and The Humber.
There appears to be a fall in positivity rates among all age groups over the past week, with rates remaining the highest among secondary school-aged children.
During the week of 22 to 28 November, ONS estimated there were 4.71 new COVID infections for every 10,000 people per day in England - equating to around 25,700 new cases per day.
The incidence rate has decreased in recent weeks.
Data of the most recent week shows that the number of positive cases in Wales is no longer falling, with an estimated 18,100 cases - meaning one in 170 people are infected.
In Northern Ireland, positivity rates peaked around the middle of October and it has continued to decrease in the most recent week.
