'How sweet it is': Sutton savours end of second wave as Queensland eyes opening border to Victorians

"Hopefully we will be doing exactly the same thing for Victoria and we'll see their case numbers today and tomorrow and be able to make that announcement," she said.

Victorian Premier Daniel Andrews confirmed there were also no new cases to report on Tuesday, for the 25th day in a row.

Mr Andrews warned despite the pleasing milestone, outbreaks could re-emerge before a vaccine is rolled out nationwide.

"Every single Victorian can be proud of the part they've played in defeating the second wave but even a big run of days, 25 days of zero, is not the same as having a vaccine," he said.

"Not everybody gets tested, and because not everybody gets tested perhaps quite as quickly as they should, we have to assume that there is more virus out there."

Click play to see how Victoria's second wave unfolded:

There were more than 9900 tests processed on Monday. On most weekdays last week, testing numbers were above 17,000.

Mr Andrews reminded Victorians with any symptoms at all to get tested quickly.

"We all still need to keep playing our part, be vigilant. We know that it's probably still out there bubbling, perhaps at a very low level."

Monash infectious diseases physician Rhonda Stuart said the recovery of the final coronavirus patient was wonderful, "not just for the team looking after them at Monash, but for the whole state," she told radio station 3AW.

The man and his wife – hospitalised since November 1 – were the last two remaining active cases in the state until the woman in her 80s was discharged from hospital on Thursday.

The couple both fell ill with the disease in early October and have pulled through after a serious battle with the virus, Dr Stuart said.

"They both had a stormy course really.. [but] they made it through and did really well," she said.

Monash Health was able to secure an exemption from state authorities to allow the couple's daughter to visit them in hospital during the darker stages of their battle with the virus.

"I think that emotional support makes a difference [to recovery]," Dr Stuart said.

"The wife was discharged last week and the gentleman was discharged last night so they could go home and be together and start living a normal life."

The treating team from Monash Health had also treated the state's first confirmed case of the virus.

Data from the Department of Health and Human Services shows that March 1 was the last time there were no active cases in Victoria.

Deputy Chief Health Officer Allen Cheng noted the absence of any active cases in the state was "certainly a milestone" given there were 7880 in Victoria on August 11.

Chief Health Officer Brett Sutton said Tuesday's triple-zero day of no new cases, no deaths and no active cases was "a testament to Victorians who endured and succeeded in a monumental task".

"How sweet it is," he wrote on Twitter. "Something to be so, so proud of."

Today also marks the first time there have been no COVID patients in Victorian hospitals since March 14 (the day the health department started publishing this figure). At the peak of the second wave there were 675 people in hospital because of coronavirus.

Meanwhile, pharmaceutical giant AstraZeneca has released results from phase three coronavirus vaccine trials showing its vaccine candidate was 70 per cent effective in preventing COVID-19.

However, the researchers also found the efficacy hit 90 per cent based on a regime where a person is given an initial half-dose followed by a second full dose.

The breakthrough is so significant that the company will start rolling out hundreds of millions of doses of its new coronavirus vaccine by Christmas.

It comes as Qantas chief executive officer Alan Joyce said international travellers hoping to come to Australia would need to be vaccinated against COVID-19.

"We are looking at changing our terms and conditions to say, for international travellers, that we will ask people to have a vaccination before they can get on the aircraft," he told A Current Affair on Monday evening.

"Whether you need that domestically, we will have to see what happens with COVID-19 in the market, but certainly, for international visitors coming out [to Australia] and people leaving the country, we think that is a necessity."

With Lydia Lynch, Bevan Shields, Mary Ward, Laura Chung