Rafael Nadal looks to build on a promising start to his quest to match Roger Federer's 20 Grand Slam titles at the French Open on Wednesday, while Serena Williams faces a familiar foe in round two of her latest push to equal Margaret Court's all-time mark.
Top seed and women's favourite Simona Halep puts her 15-match winning streak on the line as she targets another run at a second Roland Garros crown in three years.
Nadal needs one more major to pull level with long-time rival Federer and owns an astonishing 94-2 record in Paris going back to his triumph on debut in 2005.
The Spaniard showed little trouble in handling the heavier conditions in his opening win over Egor Gerasimov at a tournament postponed four months by the coronavirus pandemic.
However, the 34-year-old is wary of an untimely slip-up having made serene progress on his return to action in Rome before running aground in the quarter-finals.
"Six months without playing a single tennis match is not easy," said 12-time French Open winner Nadal, who touched down in Paris without a clay title to his name for the first time.
"I said in Rome when I played the first two matches well, I said, 'Okay, don't believe things are going to be like this.'
"I know how difficult the comebacks are. I had to stop playing tennis for more than two months, so situation is difficult. It's normal, some up and downs."
A first-time opponent again awaits Nadal in 236th-ranked American Mackenzie McDonald, whose lone tour win this season came against Yusutaka Uchiyama at Delray Beach in February.
In the women's draw, Williams heads into another encounter with Tsvetana Pironkova after the pair squared off in the last eight of the US Open earlier this month.
Williams came from a set down in New York to beat fellow mother Pironkova, in the Bulgarian's first tournament appearance since the 2017 Wimbledon championships.
"She's playing well, but I am too," said Williams, imploring herself to play with more confidence after a slow start against Kristie Ahn in round one.
"I'm ready to play her. She'll be ready to play me. It will be a long match, she will get a lot of balls back, but so will I. I'll be ready."
Williams, seeded sixth, is still chasing an elusive 24th Slam title, but clay is her least successful surface.
She has not gone beyond the last 16 in Paris since her defeat to Garbine Muguruza in the 2016 final. Her last major came at the 2017 Australian Open while pregnant.
With defending champion Ashleigh Barty skipping the event over Covid-19 concerns, world number two Halep appears well set for a tilt at a third major.
She battles fellow Romanian Irina-Camelia Begu on Court Suzanne Lenglen, having been spared the grim weather by playing under the new retractable roof in her opener.
Halep has won each of her past three tournaments, resuming the interrupted season with titles on clay in Prague and Rome following her victory at Dubai in February.
US Open champion Dominic Thiem plays American qualifier Jack Sock, a former top 10 player, in the second round while 2015 French Open winner Stan Wawrinka takes on Dominik Koepfer following his mauling of Andy Murray.
Elina Svitolina faces Renata Zarazua, Mexico's first representative in the main draw of a Slam in 20 years, with Victoria Azarenka meeting Anna Karolina Schmiedlova.
Sixth seed Alexander Zverev will come up against Pierre-Hugues Herbert in the final match scheduled on Court Philippe Chatrier.
French Open results at Roland Garros on Tuesday, the third day of the delayed 2020 championship (x denotes seeded player):
Men
First round
Novak Djokovic (SRB x1) bt Mikael Ymer (SWE) 6-0, 6-2, 6-3
Ricardas Berankis (LTU) bt Hugo Dellien (BOL) 6-1, 6-4, 6-4
Christian Garin (CHI x20) bt Philipp Kohlschreiber (GER) 6-4, 4-6, 6-1, 6-4
Marc Polmans (AUS) bt Ugo Humbert (FRA) 6-2, 6-2, 3-6, 6-3
Roberto Bautista Agut (ESP x10) bt Richard Gasquet (FRA) 7-6 (7/5), 6-2, 6-1
Attila Balazs (HUN) bt Yasutaka Uchiyama (JPN) 6-2, 6-3, 7-5
Lloyd Harris (RSA) bt Alexei Popyrin (AUS) 6-4, 6-4, 7-6 (9/7)
Matteo Berrettini (ITA x7) bt Vasek Pospisil (CAN) 6-3, 6-1, 6-3
Marcos Giron (USA) bt Quentin Halys (FRA) 7-5, 3-6, 6-7 (5/7), 7-5, 8-6
Thiago Monteiro (BRA) bt Nikoloz Basilashvili (GEO x31) 7-5, 6-4, 6-2
Dusan Lajovic (SRB x22) bt Gianluca Mager (ITA) 6-4, 7-6 (7/4), 4-6, 6-1
Kevin Anderson (RSA) bt Laslo Djere (SRB) 6-2, 6-3, 6-4
Alejandro Davidovich Fokina (ESP) bt Harold Mayot (FRA) 7-6 (7/5), 6-3, 7-5
Andrey Rublev (RUS x13) bt Sam Querrey (USA) 6-7 (5/7), 6-7 (4/7), 7-5, 6-4, 6-3
Denis Shapovalov (CAN x9) bt Gilles Simon (FRA) 6-2, 7-5, 5-7, 6-3
Roberto Carballes Baena (ESP) bt Steve Johnson (USA) 6-1, 6-1, 6-0
Andrej Martin (SVK) bt Joao Sousa (POR) 7-5, 6-1, 6-2
Grigor Dimitrov (BUL x18) bt Gregoire Barrere (FRA) 6-3, 6-2, 6-2
Pablo Cuevas (URU) bt Henri Laaksonen (SUI) 6-1, 2-6, 6-4, 6-2
Stefanos Tsitsipas (GRE x5) bt Jaume Munar (ESP) 4-6, 2-6, 6-1, 6-4, 6-4
Women
First round
Aryna Sabalenka (BLR x8) bt Jessica Pegula (USA) 6-3, 6-1
Darya Kasatkina (RUS) bt Harmony Tan (FRA) 6-2, 6-1
Nao Hibino (JPN) bt Marta Kostyuk (UKR) 6-4, 6-0
Ons Jabeur (TUN x30) bt Zarina Diyas (KAZ) 4-6, 6-3, 6-1
Clara Tauson (DEN) bt Jennifer Brady (USA x21) 6-4, 3-6, 9-7
Danielle Collins (USA) bt Monica Niculescu (ROU) 2-6, 6-2, 6-1
Elena Rybakina (KAZ x14) bt Sorana Cirstea (ROU) 6-0, 6-3
Fiona Ferro (FRA) bt Heather Watson (GBR) 7-6 (7/4), 6-4
Irina Maria Bara (ROU) bt Donna Vekic (CRO x26) 6-3, 6-4
Alison Van Uytvanck (BEL) bt Rebecca Peterson (SWE) 2-6, 6-3, 6-1
Ana Bogdan (ROU) bt Timea Babos (HUN) 6-4, 6-2
Sofia Kenin (USA x4) bt Liudmila Samsonova (RUS) 6-4, 3-6, 6-3
Petra Martic (CRO x13) bt Misaki Doi (JPN) 7-6 (7/2), 7-5
Veronika Kudermetova (RUS) bt Pauline Parmentier (FRA) 6-2, 6-3
Laura Siegemund (GER) bt Kristina Mladenovic (FRA) 7-5, 6-3
Julia Goerges (GER) bt Alison Riske (USA x19) 6-3, 6-7 (4/7), 6-1
Sloane Stephens (USA x29) bt Vitalia Diatchenko (RUS) 6-2, 6-2
Paula Badosa (ESP) bt Kateryna Kozlova (UKR) 6-2, 4-6, 6-3
Jelena Ostapenko (LAT) bt Madison Brengle (USA) 6-2, 6-1
Karolina Pliskova (CZE x2) bt Mayar Sherif (EGY) 6-7 (9/11), 6-2, 6-4