Bulandshahr court convicts rape accused to 20 years in jail within 3 months

A POCSO court also imposed a fine of Rs 50,000 on the convict, said Bulandshahr Superintendent of Police Santosh Kumar Singh.

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Updated: Sep 15, 2020, 10:18 PM IST

A court at Bulandshahr in Uttar Pradesh on Tuesday sentenced a man to 20 years in jail for raping an 11-year-girl nearly three months ago in the Khushabad village of the district. A POCSO court also imposed a fine of Rs 50,000 on the convict, said Bulandshahr Superintendent of Police Santosh Kumar Singh.

The convict Chandrapal is a resident of Didora Vishwanathpur under the Chhatari police station area. Singh said the special judge heading the court set up under the Protection of Children from Sexual Offences Act (POCSO) delivered a swift judgment within 83 days of the commission of the offence.

दुष्कर्म की घटना के आरोपी चन्द्रपाल को प्रभावी पैरवी किए जाने पर मा0 न्यायालय द्वारा 20 वर्ष सश्रम कारावास व 50,000 रूपये के अर्थदण्ड से दण्डित किए जाने के संबंध में एसएसपी द्वारा दी गई बाइट @dgpup @CMOfficeUP @UPGovt @PrashantK_IPS90 @Uppolice @adgzonemeerut @igrangemeerut pic.twitter.com/aZFSKCcyUA

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UP: Video of gang-rape of minor girl in Ballia goes viral; cops launch hunt for accused

— Bulandshahr Police (@bulandshahrpol) September 15, 2020

The case against Chandrapal was registered on June 25 on a complaint by the victim's father and acting swiftly in the case, the police arrested the accused within 12 hours. The police charge-sheeted the accused as swiftly, on the eighth day, and pursued the case diligently in the court, leading to accused conviction and sentencing within 83 days.

Bulandshahr court convicts rape accused to 20 years in jail within 3 months

Gold Price Today Domestic Gold Futures Reclaim Rs 52,100 Mark Ahead Of US Central Bank Meet

Gold Price Today: Domestic Gold Futures Reclaim Rs 52,100 Mark Ahead Of US Central Bank Meet

Gold Rate Today: The gold contract settled at Rs 52,120, up Rs 433 - or 0.84 per cent - for the day.

Gold Price Today: Domestic Gold Futures Reclaim Rs 52,100 Mark Ahead Of US Central Bank Meet

Current Gold Price In India: MCX gold futures rose to as high as Rs 52,182/10 grams during the session

Gold Price In India: Domestic gold futures moved higher on Tuesday tracking global spot rates, ahead of the beginning of a scheduled two-day meeting of the US central bank. Multi Commodity Exchange (MCX) gold futures - due for an October 5 settlement - rose by Rs 495 - or 0.96 per cent - to quote at Rs 52,182 at the strongest level recorded during the session. The gold contract settled at Rs 52,120, up Rs 433 - or 0.84 per cent - for the day. (Track Gold Futures Here)

In the international market, spot gold (Comex) rose to as high as $1,968.80 per ounce on Tuesday, its highest intraday level recorded since September 2, as a softer dollar and expectations the Federal Reserve will reinforce its accommodative monetary policy supported the yellow metal. (Also Read: Is Silver The New Gold?)

The US dollar index - which gauges the greenback against six currencies - declined as much as 0.29 per cent during the session.

Back home, spot gold settled at Rs 51,893 per 10 grams on Tuesday, excluding Goods and Services Tax, according to Mumbai-based India Bullion and Jewellers Association (IBJA).

#Gold and #Silver Closing #Rates for 15/09/2020#IBJA pic.twitter.com/CNJ59XTwu4
— IBJA (@IBJA1919) September 15, 2020

Gold has been one of the most consistent gainers through the six months of coronavirus pandemic-led turmoil in financial markets. Some analysts say gold is still in a bullish trend from a long-term perspective due to the coronavirus pandemic. (Also Read: Gold "Dream Run" May Continue: Analysts)

What Analysts Say

"Gold price continues to remain stuck in a broad range of $1,900-2,000/oz and unless there are major triggers, we may see directionless trade ahead. Mixed activity in ETF (exchange traded fund) flows also shows lack of direction in the market," said Ravindra Rao, VP-head commodity research, Kotak Securities.

"Gold may remain choppy amid lack of clear cues, however general bias may be on the upside owing to increasing challenges to global economy and hopes of dovish stance of major central banks," he added.

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Bulandshahr court convicts rape accused to 20 years in jail within 3 months

The Wnt pathway gets even more complicated -- ScienceDaily

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The Wnt pathway gets even more complicated

Date:: September 15, 2020
Source:: IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Summary:: A new role for Casein Kinase-1 on RNF43 is identified.
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The Wnt signalling pathway has been studied for decades, still it holds surprises in store. Bon-Kyoung Koo, group leader at IMBA -- Institute of Molecular Biotechnology of the Austrian Academy of Sciences and Tadasuke Tsukiyama at the Hokkaido University have now uncovered a new and unexpected role for a key component of the Wnt pathway, Casein Kinase-1, in regulating the pathway at the plasma membrane. This is the result of a study published today in Nature Communications, and broadens our understanding of the regulatory loops controlling the Wnt pathway, a pathway associated with stem cell maintenance, cell proliferation and cancer.

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In the Wnt pathway, Casein Kinase-1 is well-known as a part of the destruction complex. In the steady-state, when no Wnt signal is present, this complex destines the downstream mediator b-catenin for constant degradation. When a Wnt signal reaches the cell, the Wnt receptor Frizzled inhibits the destruction complex. This allows b-catenin to enter the nucleus, where it sets downstream responses in motion.

Casein Kinase-1 responsible for phosphoswitch of RNF43

In the newly published study, Tadasuke Tsukiyama and Bon-Kyoung Koo find that Casein Kinase-1 also regulates Wnt signalling at the plasma membrane. At the plasma membrane, the ubiquitin ligase RNF43 marks the Wnt receptor Frizzled for degradation, effectively shutting off the Wnt signalling pathway. The researchers discovered that Casein Kinase-1 triggers the switch for RNF43: When Casein Kinase-1 phosphorylates RNF43, RNF43 is activated and marks Frizzled with ubiquitin for degradation. When Casein Kinase-1 does not phosphorylate RNF43, RNF43 is inactive and signalling via Frizzled can continue. "We find that Casein Kinase-1 has an essential function in activating RNF43. With our work, we are effectively reintroducing Casein Kinase-1 to the field, defining a new role for this well-known regulator," Bon-Kyoung Koo explains.

This new understanding could lead to a novel approach for reining the Wnt pathway in cancer cells. Tsukiyama and Koo found that a mutation in RNF43's extracellular domain interrupts its function in negative feedback regulation, the tumour suppressor function of RNF43. This mutation changes RNF43 into an oncogenic form that abnormally enhances Wnt signalling. The researchers found that mimicking the phosphorylation, by adding negatively charged residues to the mutant RNF43, can revert it back to a functional tumour suppressor. With this mimicked phosphoswitch, the mutant RNF43 was again able to inhibit Frizzled. "Some patients carry a mutation in RNF43's extracellular domain. We hope that, once we know how to mimic phosphorylation in cells, this phosphorylation would revive the RNF43 tumour suppressor, enabling it to again control the Wnt pathway," Bon-Kyoung Koo adds.

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IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences. "The Wnt pathway gets even more complicated." ScienceDaily. ScienceDaily, 15 September 2020. <www.sciencedaily.com/releases/2020/09/200915105957.htm>.

IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences. (2020, September 15). The Wnt pathway gets even more complicated. ScienceDaily. Retrieved September 15, 2020 from www.sciencedaily.com/releases/2020/09/200915105957.htm

IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences. "The Wnt pathway gets even more complicated." ScienceDaily. www.sciencedaily.com/releases/2020/09/200915105957.htm (accessed September 15, 2020).

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