Serena Williams and Andy Murray are back in action on day four at the US Open in New York on Thursday.
Williams, the tournament's third seed, continues her bid for a record-equalling 24th singles Grand Slam against unseeded Russian Margarita Gasparyan.
The second-round match kicks off the evening session inside the main Arthur Ashe Stadium.
Murray will then take to the famous court to try to progress into round three at the expense of 15th seed Felix Auger-Aliassime of Canada.
The Scotsman came back from two sets down to win a thrilling five-set match first-round match against Japan's 49th-ranked Yoshihito Nishioka on Tuesday.
Murray is playing in the singles at a Grand Slam for the first time since a first-round exit at the Australian Open in 2019.
The 33-year-old is trying to rebuild his injury-ravaged career with a new metal hip that was installed last year.
Williams' chances of matching Margaret Court's record for the all-time number of Grand Slam singles titles were handed a boost on Wednesday when top seed Karolina Pliskova tumbled out of the tournament.
The Czech was stunned in straight sets by France's world No 50 Caroline Garcia.
The women's draw is missing a host of top players, either because of coronavirus fears or through injury, including top-ranked Ashleigh Barty and Simona Halep.
It has been more than three years since Williams won her 23rd Grand Slam title at the 2017 Australian Open - when she was already pregnant with daughter Olympia.
The 38-year-old has come close since, reaching four major finals only to come away empty handed.
Also on court Thursday is second seed Sofia Kenin who plays Canada's Leylah Fernandez for a place in the third round.
In the men's draw second seed Dominic Thiem of Austria goes up against Sumit Nagal, who is the first Indian man since 2013 to reach the second round of a Grand Slam.
Third see Daniil Medvedev is also gunning for a spot in the third round on Thursday, taking on Australia's 116th-ranked Christopher O'Connell.
Results from US Open tennis championship in New York on Wednesday (x-denotes seed):
Men's singles
Second round
Novak Djokovic (SRB x1) bt Kyle Edmund (GBR) 6-7 (5/7), 6-3, 6-4, 6-2
Jan-Lennard Struff (GER x28) bt Michael Mmoh (USA) 6-2, 6-2, 7-5
Pablo Carreno-Busta (ESP x20) bt Mitchell Krueger (USA) 6-1, 6-2, 6-2
Ricardas Berankis (LTU) bt Steve Johnson (USA) 7-5, 6-2, 1-6, 7-6 (7/1)
Denis Shapovalov (CAN x12) bt Kwon Soon-woo (KOR) 6-7 (5/7), 6-4, 6-4, 6-2
Taylor Fritz (USA x19) bt Gilles Simon (FRA) 7-5, 6-3, 6-2
Filip Krajinovic (SRB x26) bt Marcos Giron (USA) 6-4, 6-1, 6-3
David Goffin (BEL x7) bt Lloyd Harris (RSA) 7-6 (8/6), 4-6, 6-1, 6-4
Stefanos Tsitsipas (GRE x4) bt Maxime Cressy (USA) 7-6 (7/2), 6-3, 6-4
Borna Coric (CRO x27) bt Juan Ignacio Londero (ARG) 7-5, 4-6, 6-7 (5/7), 6-2, 6-3
Jordan Thompson (AUS) bt Egor Gerasimov (BLR) 6-1, 6-4, 3-6, 6-3
Mikhail Kukushkin (KAZ) bt Christian Garin (CHI x13) 6-2, 6-1, 3-6, 4-6, 7-5
Cameron Norrie (GBR) bt Federico Coria (ARG) 6-3, 6-4, 6-4
Alejandro Davidovich (ESP) bt Hubert Hurkacz (POL x24) 6-4, 1-6, 6-2, 6-2
Adrian Mannarino (FRA x32) bt Jack Sock (USA) 7-6 (7/5), 7-5, 6-2
Alexander Zverev (GER x5) bt Brandon Nakashima (USA) 7-5, 6-7 (8/10), 6-3, 6-1
Women's singles
Second round
Caroline Garcia (FRA) bt Karolina Pliskova (CZE x1) 6-1, 7-6 (7/2)
Jennifer Brady (USA x28) bt Catherine Bellis (USA) 6-1, 6-2
Angelique Kerber (GER x17) bt Anna-Lena Friedsam (GER) 6-3, 7-6 (8/6)
Ann Li (USA) bt Alison Riske (USA x13) 6-0, 6-3
Aliaksandra Sasnovich (BLR) bt Marketa Vondrousova (CZE x12) 6-1, 6-2
Yulia Putintseva (KAZ x23) bt Vera Lapko (BLR) 6-3, 6-3
Varvara Gracheva (RUS) bt Kristina Mladenovic (FRA x30) 1-6, 7-6 (7/2), 6-0
Petra Martic (CRO x8) bt Kateryna Bondarenko (UKR) 6-3, 6-4
Naomi Osaka (JPN x4) bt Camila Giorgi (ITA) 6-1, 6-2
Marta Kostyuk (UKR) bt Anastasija Sevastova (LAT x31) 6-3, 7-6 (7/5)
Magda Linette (POL x24) bt Danka Kovinic (MNE) 6-1, 6-7 (2/7), 7-6 (7/4)
Anett Kontaveit (EST x14) bt Kaja Juvan (SLO) 6-4, 6-1
Shelby Rogers (USA) bt Elena Rybakina (KAZ x11) 7-5, 6-1
Madison Brengle (USA) bt Dayana Yastremska (UKR x19) 6-2, 6-3
Jessica Pegula (USA) bt Kirsten Flipkens (BEL) 7-6 (7/1), 6-7 (3/7), 6-3
Petra Kvitova (CZE x6) bt Kateryna Kozlova (UKR) 7-6 (7/3), 6-2