"Dedicated clinics would have less of an impact than interventions such as vaccination, but at the statewide level, we're talking about cutting the overall number of infections by six figures," says Julie Swann, corresponding author of a paper on the work. Swann is the department head and A. Doug Allison Distinguished Professor of the Fitts Department of Industrial and Systems Engineering at North Carolina State University.

"And while our work here focused on the H1N1 strain of influenza, the findings are useful as we grapple with how best to respond to COVID-19," Swann says. "COVID-19 is more infectious than H1N1, and has a higher mortality rate. So I would expect the effect of using dedicated clinics to be larger for COVID-19."

Swann and her collaborators were inspired to do the study by the fact that some hospitals opened dedicated H1N1 clinics during the H1N1 influenza pandemic in 2009-2010. These clinics focused exclusively on treating patients who were exhibiting symptoms of H1N1. There was some question at the time as to whether these clinics were a good use of limited resources. It was also unclear as to whether the clinics may have had unintended consequences, such as spreading H1N1 to patients who showed up at the dedicated clinic with flu-like symptoms, but didn't actually have the disease.

For this study, Swann and her collaborators at Purdue University, Georgia Tech and Emory University used a simulation model to address questions related to the ultimate impact of dedicated clinics during an H1N1 pandemic.

The researchers found that opening dedicated clinics reduced disease spread and hospitalizations, particularly when open during the periods of peak prevalence -- when the most people are sick. Specifically, the researchers found that if dedicated clinics were open for the entire duration of the pandemic, the clinics would have reduced the overall number of infections by 0.4-1.5%; reduced peak prevalence (or "flattened the curve") by 0.07-0.32%; and reduced hospitalizations by 0.02-0.09%.

"For a state that has a population of 10 million, the difference in the baseline clinic case would be about 100,000 cases, with about 6,000 hospitalizations averted," Swann says. "In other words, dedicated clinics certainly don't make things worse, and can make things at least a little better. And these are benefits that come on top of any benefits we'd see from other, behavioral changes -- such as wearing masks -- which may be more difficult to implement."

North Carolina's population is approximately 10.5 million.

The study on dedicated clinics is part of a larger research initiative that has already published work examining issues related to vaccine distribution for adults and children; the role of mass gatherings and travel in spreading influenza; and the impact of seasons and mutation in the spread of the disease.

The paper, "The impact of opening dedicated clinics on disease transmission during an influenza pandemic," will be published Aug. 6 in the journal PLOS ONE. The paper was co-authored by Pengyi Shi of Purdue University; Jia Yan and Pinar Keskinocak of Georgia Tech; and by Dr. Andi Shane of Emory University and Children's Healthcare of Atlanta. The work was done with support from Georgia Tech, Edward P. Fitts and the A. Doug Allison Distinguished Professorship.

Story Source:

Materials provided by North Carolina State University. Note: Content may be edited for style and length.

Journal Reference:

1. Pengyi Shi, Jia Yan, Pinar Keskinocak, Andi L. Shane, Julie L. Swann. The impact of opening dedicated clinics on disease transmission during an influenza pandemic. PLOS ONE, 2020; 15 (8): e0236455 DOI: 10.1371/journal.pone.0236455