Patients with Alzheimer's disease frequently suffer from spatial memory loss, such as no recognition of where they are, and forgetting where they put their belongings. They often show a wandering symptom, which is also a feature of spatial memory impairment. A team of researchers has now brought clarity on the brain network mechanism that causes spatial memory impairment. The study, done Alzheimer's disease model mice, found that this disruption of the hippocampus is most likely caused by the activity impairment of the entorhinal cortex, a brain region that supplies information to the hippocampus.