
Event Highlights
A combination of antiviral drugs commonly used to treat HIV showed no beneficial effects in patients hospitalised with COVID-19 in a large-scale randomised trial, scientists in the UK have found. The findings "convincingly rule out any meaningful mortality benefit of lopinavir-ritonavir in the hospitalised COVID-19 patients we studied," the scientists running the RECOVERY trial at the University of Oxford said in a statement on Monday. In March, the RECOVERY trial was established as a randomised clinical trial to test a range of potential treatments for COVID-19, including lopinavir-ritonavir, an antiviral treatment commonly used to treat HIV. Over 11,800 patients have been enrolled from 176 NHS hospitals in the UK for the trial. On Monday, the trial Steering Committee concluded that there is no beneficial effect of lopinavir-ritonavir in patients hospitalised with COVID-19.
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— Delhi Metro Rail Corporation (@OfficialDMRC) June 30, 2020
In light of the guidelines issued by the government, Metro services will remain closed for commuters until further notice.
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Delhi: Prime Minister Narendra Modi today chaired a high-level meeting to review the preparations being undertaken for vaccination against #COVID19, as and when a vaccine is available. pic.twitter.com/HaAOIKX2wp
— ANI (@ANI) June 30, 2020
HIV Drug Combo Showed No Benefit in UK | A combination of antiviral drugs commonly used to treat HIV showed no beneficial effects in patients hospitalised with COVID-19 in a large-scale randomised trial, find scientists in the UK. In March, the RECOVERY trial was established as a randomised clinical trial to test a range of potential treatments for COVID-19, including lopinavir-ritonavir, an antiviral treatment commonly used to treat HIV. Over 11,800 patients have been enrolled from 176 NHS hospitals in the UK for the trial. READ MORE
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For representation. (AP)
A total of 1,596 patients were randomised to lopinavir-ritonavir and compared with 3,376 patients randomised to usual care alone, the statement said. Of these patients, four per cent required invasive mechanical ventilation when they entered the trial, 70 per cent required oxygen alone, and 26 per cent did not require any respiratory intervention, it said. There was no significant difference in mortality for lopinavir-ritonavir compared to usual care, and the results were consistent in different subgroups of patients, the scientists said.
There was also no evidence of beneficial effects on the risk of progression to mechanical ventilation or length of hospital stay, they said. "These preliminary results show that for patients hospitalised with COVID-19 and not on a ventilator, lopinavir-ritonavir is not an effective treatment. In 100 days, the RECOVERY trial has provided results enabling change in global practice three times," said Peter Horby, Professor at the University of Oxford, and chief investigator for the trial.
The researchers said they were unable to study a large number of patients on invasive mechanical ventilation because of difficulty administering the drug to patients on ventilators. As such, they cannot make conclusions about the effectiveness in mechanically ventilated patients, the researchers said, adding full results will be made available as soon as possible. "These are clear results and once again emphasise the value of large randomised clinical trials in differentiating drugs we hope work from treatments we know do work," said Martin Landray, Professor of Medicine and Epidemiology at the University of Oxford.
"In many countries, current guidelines recommend lopinavir-ritonavir as a treatment for COVID-19," said Landray, Deputy Chief Investigator of the trial. The results from this trial, together with those from other large randomised trials, should inform revisions to those guidelines and changes to the way individual patients are treated, the researchers said.
ix months on from the novel coronavirus outbreak, the WHO said Monday it was sending a team to China to work towards finding the source as it warned the pandemic was far from over. And the World Health Organization warned that in an atmosphere of global division and politicisation of the COVID-19 crisis, it feared the worst was yet to come. The UN health agency lamented the "very tragic" milestones of 500,000 deaths and 10 million confirmed infections being reached, just as it marks on Tuesday six months since it was first informed of the outbreak in the Chinese city of Wuhan.
The WHO is sending a team to China next week in connection with the search for the origin of the virus that sparked the global pandemic. The organisation has been pressing China since early May to invite in its experts to help investigate the animal origins of the coronavirus. "We can fight the virus better when we know everything about the virus, including how it started," WHO director-general Tedros Adhanom Ghebreyesus told a virtual press conference. "We will be sending a team next week to China to prepare for that and we hope that that will lead into understanding how the virus started."
He did not specify the make-up of the team, nor what specifically their mission would consist of. Scientists believe the virus jumped from animals to humans, possibly from a market in Wuhan selling exotic animals for meat.
'We fear the worst'
"Six months ago, none of us could have imagined how our world -- and our lives -- would be thrown into turmoil by this new virus," said Tedros. "We all want this to be over. We all want to get on with our lives. But the hard reality is this is not even close to being over.
"Globally the pandemic is actually speeding up. We're all in this together, and we're all in this for the long haul. We have already lost so much -- but we cannot lose hope."
Tedros also said that the pandemic had brought out the best and worst humanity, citing acts of kindness and solidarity, but also misinformation and the politicisation of the virus. Unless international unity replaces fractious division, "the worst is yet to come. I'm sorry to say that," he said. "With this kind of environment and condition, we fear the worst."
While the world races to find safe and effective vaccines and therapeutics against COVID-19, Tedros said countries such as South Korea had shown that the virus could be successfully suppressed and controlled without them. He said governments needed to be "serious" about measures such as contact tracing, and citizens had to take responsibility for personal steps such as maintaining hand hygiene.
Reflecting on the global death toll and infection numbers, Tedros said: "Still, this could have been prevented through the tools we have at hand." He added: "The critical question that all countries will face in the coming months is how to live with this virus. That is the new normal."
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