Through examining a broad range of studies, a full picture emerged of the severe impact that loneliness can have:

• having strong interpersonal relationships is critical for survival across the entire lifespan;
• social isolation is a significant predictor of the risk of death;
• insufficient social stimulation affects reasoning and memory performances, hormone homeostasis, brain grey/white-matter, connectivity and function, as well as resilience to physical and mental disease;
• feelings of loneliness can spread through a social network, causing negatively skewed social perception, escalating morbidity and mortality, and, in older people, precipitating the onset of dementia such as Alzheimer's disease.

Loneliness directly impairs the immune system, making us less resistant to diseases and infections. Indeed, feeling lonely and having few friends can result in a particularly poor immune defence. People who are more socially integrated, however, have better adjusted biomarkers for physiological function, including lower systolic blood pressure, lower body mass index, and lower levels of C-reactive protein (another molecular response to inflammation).

Humans are intensely social and benefit psychologically and physically from social interaction. The tighter we are embedded in a network of friends, for example, the less likely we are to become ill and the higher our rates of survival. People who belong to more groups, such as sports clubs, church, hobby groups, have been found to reduce their risk of future depression by almost 25%.

Associate Professor Department of Biomedical Engineering at McGill University & Canada CIFAR Artificial Intelligence Chair Danilo Bzdok, said: "We are social creatures. Social interplay and cooperation have fuelled the rapid ascent of human culture and civilization. Yet, social species struggle when forced to live in isolation. From babies to the elderly, psychosocial embedding in interpersonal relationships is critical for survival. It is now more urgent than ever to narrow the knowledge gap of how social isolation impacts the human brain as well as mental and physical well-being."

Emeritus Professor of Evolutionary Psychology Robin Dunbar, said: "Loneliness has accelerated in the past decade. Given the potentially severe consequences this can have on our mental and physical health, there is growing recognition and political will to confront this evolving societal challenge. As one consequence, the United Kingdom has launched the 'Campaign to End Loneliness' -- a network of over 600 national, regional and local organizations to create the right conditions for reducing loneliness in later life. Such efforts speak to the growing public recognition and political will to confront this evolving societal challenge. These concerns can only be exacerbated if there are prolonged periods of social isolation imposed by national policy responses to extraordinary crises such as COVID-19."

Editor's Note

This news release is also available from the University of Oxford at: http://www.ox.ac.uk/news/2020-06-05-neurobiology-social-distance-why-loneliness-may-be-biggest-threat-survival-and

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Materials provided by McGill University. Note: Content may be edited for style and length.

Journal Reference:

1. Danilo Bzdok, Robin I.M. Dunbar. The Neurobiology of Social Distance. Trends in Cognitive Sciences, 2020; DOI: 10.1016/j.tics.2020.05.016