Neural circuit that drives physical responses to emotional stress found

Emotional stress activates the sympathetic nervous system, which leads to physical responses, such as a rise in blood pressure and body temperature, and a faster heart rate. Such responses are thought to be coping mechanisms in humans and many other mammals to boost physical performance in fight-or-flight situations. But nowadays, when most people rarely encounter such situations, these responses could perhaps have an adverse effect on their health. Excessive stress may cause symptoms such as psychogenic fever, a condition of abnormally high body temperature.

To develop strategies for treating stress-induced symptoms, the neural mechanism underlying physical responses to stress had first to be understood. To this end, a research team led by Professor Kazuhiro Nakamura and Designated Assistant Professor Naoya Kataoka, of the Nagoya University Graduate School of Medicine, conducted a study in which tracers were injected into the brains of a group of rats and the rats were subjected to a stressful event (rat bullying by a dominant rat).

The tracers showed that specifically the DP/DTT brain areas were highly active when exposed to stress. To further examine the role these brain areas have in stress response, the researchers impaired the areas' connections to the hypothalamus and again exposed the rats to the same stress. Now the rats did not exhibit any stress-induced physical response, neither a rise in blood pressure nor body temperature, nor a faster heart rate.

This study demonstrates that the DP/DTT areas together are responsible for sending stress signals to the hypothalamus, and thus that blocking the DP/DTT-to-hypothalamus circuit can result in a reduction of stress symptoms in rats.

Professor Nakamura sums up the research result like this: "The DP/DTT are parts of the brain that are involved in processing emotion and stress. The DP/DTT-to-hypothalamus pathway we discovered, therefore, represents a brain mechanism for a 'mind-body connection,' which can be a potential target for treating stress-related disorders such as panic disorder, post-traumatic stress disorder (PTSD), and psychogenic fever."

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Materials provided by Nagoya University. Note: Content may be edited for style and length.

Journal Reference:

1. Naoya Kataoka, Yuta Shima, Keisuke Nakajima, Kazuhiro Nakamura. A central master driver of psychosocial stress responses in the rat. Science, 2020; 367 (6482): 1105 DOI: 10.1126/science.aaz4639