A truck driver suffered serious injuries after his vehicle left the road and rolled, scattering parts and tools across a central Queensland highway.

The crash happened on the Dawson Highway between Banana and Biloela, about 115 kilometres south of Rockhampton, just after 3.30pm on Monday.

The driver, a 58-year-old man from the Biloela area, was flown to the Rockhampton Base hospital in a serious condition by helicopter.

According to an RACQ Capricorn Rescue Helicopter spokesperson, the man suffered internal injuries and possible fractures.

"Tools and parts of the truck were scattered over a large area of the road, causing a lengthy clean-up process and closing that part of the Dawson Highway for several hours," the spokesperson said.

Forensic Crash Unit investigators have appealed for any witnesses travelling along that section of the Dawson Highway between 3pm and 3.30pm, or anyone with dashcam vision, to contact police.