The metabolic reprogramming of immune cells, a strategy that has potential against cancer, also has potential against HIV. According to scientists at the Institut Pasteur, metabolic reprogramming can induce killer T cells from HIV noncontrollers to emulate the antiviral capabilities of killer T cells from HIV controllers. The scientists have shown that interleukin-15 can be used to boost the mitochondrial activity and anti-HIV potential of noncontrollers’ cells.
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Original Article: HIV Controller T Cells Share Energy Omnivore Secrets