We are grateful to Jennifer Tufts, George Tang, and Jay Parekh for their thoughtful comments on our Article1 and appreciate the opportunity to discuss our study data in more detail and provide clarification. First, we agree with Tufts that the aetiology of post-partum depression might differ on the basis of its time of onset. However, the proportions of patients with symptom onset in the third trimester in study 2 (22% in both placebo and brexanolone 90 μg/kg per h arms) and the integrated analysis (28% in the placebo group, 26% in those taking 60 μg/kg per h brexanolone, and 22% in those in the 90 μg/kg per h group) are comparable.