Foundation Medicine, Inc. today announced that new data informed by the use of its portfolio of comprehensive genomic profiling (CGP) tests will be presented at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place from May 31 to June 4 in Chicago. The company and its collaborators will present a total of 18 studies, including two poster discussions.
Highlights of these presentations include:
Data to be presented support the clinical use of tissue and liquid CGP tests and demonstrate the importance of genomic biomarkers to help inform selection of targeted therapies, including immunotherapies, across a variety of advanced tumor types.
“We are excited to share new data derived from the use of comprehensive genomic profiling to further characterize the molecular underpinnings of cancer and provide additional evidence of the role of biomarkers in optimizing precision medicine approaches,” said Brian Alexander, M.D., M.P.H., chief medical officer at Foundation Medicine. “Given the continued pace of innovation for targeted and immunotherapies, the clinically relevant insights derived from comprehensive genomic profiling, including those from Foundation Medicine and Flatiron Health’s unique database of clinico-genomic information, are a vital source of information to support the development of such therapies and can help improve clinical decision-making and patient care.”
Tumor Mutational Burden (TMB) as Predictor of Response to Immunotherapy
In one study, more than 3,800 metastatic breast cancer samples were
classified as HER2 negative (ER+/HER2-), HER2 amplified and triple
negative breast cancer. The study showed that TMB can help predict
responsiveness to immunotherapy, which has been difficult to show in
metastatic breast cancer patients, across all three subtypes.
[Immunotherapy
predictive biomarkers in metastatic breast cancer (MBC). Poster
discussion. Abstract 1023, Poster #104. June 2, 8:00am – 11:00am, Hall
A. Poster Discussion – June 2, 11:15am – 12:45pm, Hall D2.]
Another study to be presented by Friends of Cancer Research found it is
feasible to standardize the measurement of TMB across different CGP
testing platforms, including FoundationOne®CDx. These data
were drawn from the findings of the organization’s TMB Harmonization
Project, which aims to establish best practices to improve consistency
and reliability of TMB estimation across platforms in the interest of
optimizing the clinical utility of TMB in cancer care through engaging a
coalition of research and industry organizations, including Foundation
Medicine.
[TMB standardization by alignment to reference
standards: Phase II of the Friends of Cancer Research TMB Harmonization
Project. Abstract 2624, Poster #268. June 1, 8:00am – 11:00am,
Hall A. Presented by Friends of Cancer Research.]
Utility of Comprehensive Genomic Profiling
In a retrospective analysis, more than 200,000 relapsed or refractory
cancers were evaluated to determine how pan-tumor FGFR2 genomic
alterations co-occur with other genomic alterations including TMB,
microsatellite instability (MSI), and PD-L1 expression. Cancers with an FGFR2
receptor tyrosine kinase (RTK) alteration were shown to have higher
frequency of elevated TMB than cancers with other RTK alterations,
suggesting potential immunotherapy responsiveness.
[FGFR2: A
pan-genomic target. Abstract 3099, Poster #91. June 1, 8:00am –
11:00am, Hall A.]
In another retrospective analysis, researchers evaluated more than 2,000
primary and metastatic urothelial cancer cases, the largest analysis of
its kind. All classes of genomic alterations were evaluated in two
subtypes of the cancer: upper tract and bladder tumors. FGFR3 was
found more frequently in upper tract tumors (26 percent of cases) than
in bladder tumors (19 percent of cases). Overall, 48 percent of all
tumors harbored genomic alterations that could benefit from approved or
investigational targeted therapies, suggesting CGP should be
incorporated into routine evaluation of metastatic urothelial cancer
before initiating treatment.
[Comprehensive genomic profiling
(CGP) of upper-tract (UTUC) and bladder (BUC) urothelial carcinoma
reveals opportunities for therapeutic and biomarker development. Abstract
4581, Poster #346. June 3, 1:15pm – 4:15pm, Hall A. Poster Discussion –
June 3, 4:30pm – 6:00pm, Hall D2.]
A study characterizing NSCLC cases found HER2 exon 20 insertion
mutations in 1.5 percent (n=648) of NSCLC cases analyzed and noted that
these are generally mutually exclusive of other known drivers. Detection
of these alterations using tissue or liquid CGP may be critical to
identify matched targeted therapy options, which have recently shown
efficacy in the clinic, for this subset of patients.
[Characterization
of 648 non-small cell lung cancer (NSCLC) cases with 28 unique HER2 exon
20 insertions. Abstract 9063. Poster #386. June 2, 8:00am – 11:00am,
Hall A.]
Using Data to Advance Precision Medicine
Another ASCO presentation will share data from a clinico-genomic
database, which includes more than 50,000 de-identified matched profiles
linking comprehensive genomic profiling results from Foundation Medicine
with patient outcomes data from Flatiron Health’s electronic health
records database. The study evaluated more than 400 advanced NSCLC
patients and showed that combining the biomarkers TMB and PD-L1
expression can predict response to immunotherapy better than either of
these markers alone, reinforcing the importance of testing patients for
both biomarkers to inform treatment strategies.
[Tumor
mutational burden (TMB) and PD-L1 expression as predictors of response
to immunotherapy (IO) in NSCLC. Abstract 2630, Poster #274. June
1, 8:00am – 11:00am, Hall A. Presented by Flatiron Health.]
The following is a list of select abstracts that will be presented at the meeting. For a full list of the data being presented by Foundation Medicine and its collaborators, please visit: http://info.foundationmedicine.com/asco2019
| Abstract # | Title | Collaborator | Day/Time | Location | ||||
| Foundation Medicine Poster Discussions | ||||||||
| 1023 | Immunotherapy predictive biomarkers in metastatic breast cancer (MBC). |
June 2:
Poster Discussion – 11:15am –12:45pm |
Hall A
Hall D2 |
|||||
|
4581 |
Comprehensive genomic profiling (CGP) of upper-tract (UTUC) and bladder (BUC) urothelial carcinoma reveals opportunities for therapeutic and biomarker development. |
|
June 3: Poster Display – 1:15pm –4:15pm
Poster Discussion - 4:30pm –6:00pm |
Hall A
Hall D2 |
||||
| Foundation Medicine Posters | ||||||||
| 3099 | FGFR2: A pan-genomic target. | June 1, 8:00am – 11:00am | Hall A | |||||
| 6557 | Accelerating advanced precision medicine through a harmonized data exchange platform and research consortium (PMEC). | June 1, 1:15pm – 4:15pm | Hall A | |||||
| 9063 | Characterization of 648 non-small cell lung cancer (NSCLC) cases with 28 unique HER2 exon 20 insertions. | June 2, 8:00am – 11:00am | Hall A | |||||
| 3533 | RAS-amplified colorectal cancers: Microsatellite stability status, RAS/BRAF mutations, and prediction of anti-EGFR resistance. | June 3, 8:00am – 11:00am | Hall A | |||||
| 4545 | Analysis of EGFR mutant urothelial carcinoma (UC) reveals distinct mutational landscape. | June 3, 1:15pm – 4:15pm | Hall A | |||||
| 9566 | Anal melanoma: A comparative comprehensive genomic profiling study. | June 3, 1:15pm – 4:15pm | Hall A | |||||
| 9591 | Extra-mammary Paget’s disease (EMPD) of the skin: A comprehensive genomic profiling (CGP) study. | June 3, 1:15pm – 4:15pm | Hall A | |||||
| Foundation Medicine and Collaborator Presentations | ||||||||
| 2630 | Tumor mutational burden (TMB) and PD-L1 expression as predictors of response to immunotherapy (IO) in NSCLC. | Flatiron Health | June 1, 8:00am – 11:00am | Hall A | ||||
| 2624 | TMB standardization by alignment to reference standards: Phase II of the Friends of Cancer Research TMB Harmonization Project. | Friends of Cancer Research | June 1, 8:00am – 11:00am | Hall A | ||||
| 4080 | Comprehensive genomic profiling in FIGHT-202 reveals the landscape of actionable alterations in advanced cholangiocarcinoma. | Incyte | June 3, 8:00am – 11:00am | Hall A | ||||
| 4087 | Profiling of 3,634 cholangiocarcinomas (CCA) to identify genomic alterations (GA), tumor mutational burden (TMB) and genomic loss of heterozygosity (gLOH). | MD Anderson | June 3, 8:00am – 11:00am | Hall A | ||||
| 4535 | Squamous-cell carcinoma variant histology (SCC-VH) in muscle-invasive bladder cancer (MIBC): A comprehensive clinical, genomic, and therapeutic assessment from multiple dataset. | Fondazione IRCCS Istituto Nazionale dei Tumori | June 3, 1:15pm – 4:15pm | Hall A | ||||
About Foundation Medicine
Foundation Medicine is a molecular
information company dedicated to a transformation in cancer care in
which treatment is informed by a deep understanding of the genomic
changes that contribute to each patient's unique cancer. The company
offers a full suite of comprehensive genomic profiling assays to
identify the molecular alterations in a patient’s cancer and match them
with relevant targeted therapies, immunotherapies and clinical trials.
Foundation Medicine’s molecular information platform aims to improve
day-to-day care for patients by serving the needs of clinicians,
academic researchers and drug developers to help advance the science of
molecular medicine in cancer. For more information, please visit www.FoundationMedicine.com
or follow Foundation Medicine on Twitter (@FoundationATCG).
Foundation Medicine® and FoundationOne®CDx are registered trademarks of Foundation Medicine, Inc.
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Lee-Ann Murphy, 617-245-3077
pr@foundationmedicine.com