The Monash Freeway has completely re-opened after a multi-car crash shut outbound lanes and caused heavy peak-hour delays.

Three lanes were closed between Eastlink and Stud Road at about 6pm on Wednesday and speed was set at 40km/h in the remaining lanes.

At one point, queues were stretching back to Toorak Road but traffic is now clear.

It is not believed there were any serious injuries in the crash.