Extra-intestinal pathogenic Escherichia coli (ExPEC) are responsible for almost as many severe infections as pneumococci or meningococci. Estimates of E coli bacteraemia and sepsis in the health-care system in the USA suggest that more than 85 000 deaths are due to E coli sepsis.1 Additionally, multidrug resistance is an increasing problem, especially in E coli, and even more pronounced in severe infections, such as urosepsis.2 Alternative anti-infective strategies, such as a specific vaccine against ExPEC, would definitively increase the options for the treatment of invasive E coli disease and could be considered a great clinical advantage and contribute to decreasing antibiotic selection pressure.
Original Article: [Comment] A step further in a vaccine for Escherichia coli