Tottenham was beaten for the first time at its new stadium as Michail Antonio fired West Ham to a surprise 1-0 victory over its London rival on Saturday.
Mauricio Pochettino’s side had won all four matches at its new £1 billion Tottenham Hotspur stadium.
But Antonio’s clinical second half strike ended that run as the West Ham winger became the first visiting player to score in the plush arena.
Third placed Tottenham’s second defeat in its last three Premier League games put a dent in its bid to finish in the top four.
It holds a three-point lead over fourth placed Chelsea and is four points ahead of fifth placed Arsenal, with both teams in action on Sunday.
It was a frustrating warm-up for Tottenham’s Champions League semifinal first leg against Ajax in north London on Tuesday.
Gone in 15 seconds
Liverpool powered back to the top of the Premier League as Naby Keita’s goal after just 15 seconds inspired a 5-0 rout of Huddersfield on Friday.
Jurgen Klopp’s side struck three times in the first half at Anfield, with Keita bagging Liverpool’s fastest ever Premier League goal before Sadio Mane and Mohamed Salah also got on the scoresheet.
Mane and Salah netted again in the second half to move the Reds two points clear of second placed Manchester City, which will regain pole position if it wins at Burnley on Sunday.
The lead at the top of the table has now changed hands for a record 29th time as this memorable season heads for a thrilling conclusion.
The results: Premier League: Tottenham 0 lost to West Ham 1 (Antonio 67); Crystal Palace 0 drew with Everton 0; Fulham 1 (Babel 79) bt Cardiff City 0; Southampton 3 (Long 12, Ward-Prowse 55, Targett 67) drew with Bournemouth 3 (Gosling 20, Wilson 32, 86); Watford 1 (Gray 49) lost to Wolves 2 (Jiminez 41, Jota 77).
La Liga: Athletic Bilbao 1 (Benat 41) drew with Alaves 1 (Borja 45).
Serie A: Bologna 3 (Soriano 52, Orsolini 83, Sansone 90+5) bt Empoli 1 (Pajac 17).
Bundesliga: Borussia Dortmund 2 (Goetze 14, Witsel 84) lost to Schalke 4 (Caligiuri 18-pen, 62, Sane 28, Embolo 86); RB Leipzig 2 (Werner 19, Forsberg 78-pen) bt Freiburg 1 (Grifo 67); Eintracht Frankfurt 0 drew with Hertha Berlin 0; Hanover 1 (Weydandt 66) bt Mainz 0; Fortuna Dusseldorf 4 (Raman 1, Karaman 23, Hennings 56, Suttner 73) bt Werder Bremen 1 (Kruse 28-pen).
On Friday: Premier League: Liverpool 5 (Keita 1, Mane 23, 66, Salah 45+1, 83) bt Huddersfield 0.
Bundesliga: Augsburg 1 (Danso 12) lost to Bayer Leverkusen 4 (Volland 15, Havertz 49, Tah 60, Brandt 88).