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Lufthansa is reporting a first quarter operating loss of 336 million euros, or $380 million.
The news sent its shares down on Tuesday.
Germany's biggest airline says that a 202 million euro rise in fuel costs had contributed to their woes, along with excess passenger capacity across Europe.
Ticket prices have also fallen significantly at Lufthansa's other airlines.
They include SWISS and Austrian Airlines, as well as budget carrier Eurowings.
The size of the loss was far greater than analysts had expected.
Particularly, compared to the same period last year when it reported a 52 million euro profit.
Lufthansa's stock was down 1 percent in morning trade, underperforming Germany's bluechip index by around 2 percent and dragging down shares of rivals Ryanair and Air France.
Lufthansa's loss added weight to concerns across the industry and follows a similarly bleak report from easyJet It reported earlier this month that it expected a 317 million euro loss in the six months to the end of March.
As well as battling overcapacity and high fuel costs, European airlines are facing uncertainty around Brexit which has led some travellers to delay booking flights for their summer holidays.