Lionel Messi will miss Argentina's friendly against Morocco next week after picking up a groin injury in the shock 3-1 defeat to Venezuela on Friday as he made his first international appearance since the 2018 World Cup.
The Argentine Football Federation tweeted the injury update following the loss at Atletico Madrid's Wanda Metropolitano stadium.
Gonzalo Martinez has also been ruled out of the fixture in Tangier with a thigh problem.
Salomon Rondon and Jhon Murillo gave Venezuela a two-goal advantage at the break.
Argentina forward Lautaro Martinez halved the deficit before Josef Martinez scored from the spot to claim the spoils in the friendly.
Messi's 129th cap started poorly as Newcastle forward Rondon controlled a long ball before hammering home a half-volley past Argentine goalkeeper Franco Armani. The pick of the goals came as 23-year-old Murillo scored for only a third time in 17 internationals.
He received the ball on the corner of the box, was given plenty of space by the Albiceleste defence and the winger fired home powerfully past Armani with a minute left of the first half Argentina's Martinez gave his side some hope on the hour mark as Messi found Giovanni Lo Celso who played in the Inter forward to finish.
Rafael Dudamel's side, ranked 32nd in the world, claimed a third after Martinez was tripped in the box.
The Atlanta United attacker skipped up to take the penalty, sending Armani the wrong way to score with 15 minutes remaining.
The friendly against Morocco on Tuesday comes as they prepare for this year's Copa America, held in Brazil between June-July.
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