(University of Louisville) An immune checkpoint molecule developed for cancer immunotherapy also protects against future development of multiple types of cancer when administered by itself. The recombinant protein molecule SA-4-1BBL has been used to enhance the therapeutic efficacy of cancer vaccines with success in pre-clinical animal models. Surprisingly, when the researchers treated normal, healthy mice with SA-4-1BBL alone, the mice were protected when the researchers later exposed them to different types of tumor cells.
Original Article: Immune stimulant molecule shown to prevent cancer