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Here are what the editors at HealthDay consider to be the most important developments in Pathology for January 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
THURSDAY, Jan. 31, 2019 -- New symptom combinations that may indicate early symptoms of laryngeal cancer have been identified, according to a study published online Jan. 28 in the British Journal of General Practice.
FRIDAY, Jan. 25, 2019 -- Higher lean body mass during childhood and adolescence is associated with higher lung function at age 15 years for both sexes, according to a study published online Jan. 11 in the American Journal of Respiratory and Critical Care Medicine.
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THURSDAY, Jan. 24, 2019 -- Higher childhood blood lead levels are associated with more psychopathology during the life course, according to a study published online Jan. 23 in JAMA Psychiatry.
FRIDAY, Jan. 25, 2019 -- An improved type 1 diabetes (T1D) genetic risk score (GRS), the T1D GRS2, is highly useful for classifying adult incident diabetes type and improving newborn screening, according to a study published in the February issue of Diabetes Care.
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FRIDAY, Jan. 25, 2019 -- In a report published in the January issue of Value in Health, an ISPOR--The Professional Society for Health Economics and Outcomes Research working group indicates the lack of good practices in three areas of health technology assessment (HTA).
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THURSDAY, Jan. 24, 2019 -- Donor-derived cell-free DNA (ddcfDNA) is a potential biomarker that can predict allograft failure after lung transplantation, according to a study published online Jan. 23 in EBioMedicine.
THURSDAY, Jan. 24, 2019 -- In young adults, lower gray matter volume (GMV) is seen in individuals with blood pressure (BP) >120/80 mm Hg, according to a study published online Jan. 23 in Neurology.
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THURSDAY, Jan. 24, 2019 -- Cigarette smoking is associated with measures of subclinical peripheral artery disease (PAD) in African-Americans, according to a study published online Jan. 23 in the Journal of the American Heart Association.
WEDNESDAY, Jan. 23, 2019 -- For women undergoing in vitro fertilization (IVF), endometrial scratching by pipelle biopsy between day 3 of the cycle preceding the embryo-transfer cycle and day 3 of the embryo-transfer cycle, does not result in a higher rate of live birth, according to a study published in the Jan. 24 issue of the New England Journal of Medicine.
TUESDAY, Jan. 22, 2019 -- A substantial proportion of patients with newly diagnosed cancer and concurrent hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are unaware of their viral infection at the time of cancer diagnosis, according to a study published online Jan. 17 in JAMA Oncology.
TUESDAY, Jan. 22, 2019 -- Whole-exome sequencing (WES) can identify a genetic cause for almost one-third of pediatric kidney transplant recipients, according to a study published online Jan. 17 in the Journal of the American Society of Nephrology.
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FRIDAY, Jan. 18, 2019 -- Frailty and Alzheimer disease-related brain changes independently contribute to dementia status, according to a study published in the February issue of The Lancet Neurology.
THURSDAY, Jan. 17, 2019 -- Due to the federal government shutdown, the U.S. Food and Drug Administration has only about five weeks of funding left to review new drug applications, according to Commissioner Scott Gottlieb, M.D.
THURSDAY, Jan. 17, 2019 -- HFE p.C282Y homozygosity, the most common gene mutation causing hereditary hemochromatosis (type 1), is associated with other morbidity in men and women, according to a study published online Jan. 16 in The BMJ.
THURSDAY, Jan. 17, 2019 -- Two patients diagnosed with acute flaccid myelitis and upper-extremity neuropathy who were treated with peripheral nerve transfer continue to demonstrate functional recovery at two years, according to a case series recently published in Pediatric Neurology.
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THURSDAY, Jan. 17, 2019 -- Among breast cancer patients, more extensive genetic testing is not associated with increased cancer worry, according to a study recently published in JCO Precision Oncology.
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WEDNESDAY, Jan. 16, 2019 -- The incidence and progression of coronary artery calcium (CAC) in South Asians may be an important prognostic marker of cardiovascular disease, according to a study published online Jan. 11 in the Journal of the American Heart Association.
WEDNESDAY, Jan. 16, 2019 -- In older adults, higher levels of total daily activity and better motor abilities are associated with better cognition, according to a study published online Jan. 16 in Neurology.
WEDNESDAY, Jan. 16, 2019 -- Adoption of advanced health information technology (HIT) capabilities is inconsistent across health care systems, with electronic health record (EHR) standardization being the strongest predictor of advanced capabilities, according to a study published in the January issue of the American Journal of Managed Care.
WEDNESDAY, Jan. 16, 2019 -- The rates of complications after invasive diagnostic procedures for lung abnormalities are higher in the community setting than in clinical trials, according to a study published online Jan. 14 in JAMA Internal Medicine.
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TUESDAY, Jan. 15, 2019 -- Breakdown of the blood-brain barrier (BBB) may be an early biomarker of cognitive dysfunction, independent of amyloid or tau marker status, according to a study published online Jan. 14 in Nature Medicine.
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TUESDAY, Jan. 15, 2019 -- For patients with relapsing-remitting multiple sclerosis (MS), nonmyeloablative hematopoietic stem cell transplantation (HCST) is associated with prolonged time to disease progression compared with disease-modifying therapy (DMT), according to a study published in the Jan. 15 issue of the Journal of the American Medical Association.
TUESDAY, Jan. 15, 2019 -- There have been 600 confirmed cases of Ebola and 347 confirmed deaths since early August in the Democratic Republic of the Congo, making this outbreak of the disease the second largest and second deadliest in history.
TUESDAY, Jan. 15, 2019 -- The influence of heritability and environmental factors has been identified for a large number of phenotypes, according to a study published online Jan. 14 in Nature Genetics.
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TUESDAY, Jan. 15, 2019 -- Ethical principles are discussed in an updated Ethics Manual, issued by the American College of Physicians (ACP) and published as a supplement to the Jan. 15 issue of the Annals of Internal Medicine.
TUESDAY, Jan. 15, 2019 -- Patients with Tourette syndrome (TS) or chronic tic disorder (CTD) have an increased risk for developing at least one metabolic or cardiovascular disorder, according to a study published online Jan. 14 in JAMA Neurology.
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MONDAY, Jan. 14, 2019 -- An American doctor who was monitored for 21 days after possible Ebola exposure did not develop the deadly disease and has been released from the Nebraska Medicine-Nebraska Medical Center in Omaha, officials say.
MONDAY, Jan. 14, 2019 -- Among individuals with posttraumatic stress disorder (PTSD), those who were victims of terrorist attacks (TA) have a higher risk for neoplasms than those who experience other traumatic events (OTE), according to a study published online Jan. 8 in the Journal of Neuroscience Research.
MONDAY, Jan. 14, 2019 -- Moderate alcohol consumption is associated with lower atrial voltage and conduction slowing in patients with atrial fibrillation (AF), according to a study published online Jan. 9 in Heart Rhythm.
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MONDAY, Jan. 14, 2019 -- The median overall survival (OS) from diagnosis for patients with stage IV anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) is 6.8 years, according to a study published online Dec. 29 in the Journal of Thoracic Oncology.
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FRIDAY, Jan. 11, 2019 -- Artificial intelligence (AI) can identify asymptomatic left ventricular dysfunction (ALVD) using results from a routine electrocardiogram (ECG), according to a research letter published online Jan. 7 in Nature Medicine.
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FRIDAY, Jan. 11, 2019 -- The difference in health spending between the United States and other countries is still explained by health care prices, according to a study published in the January issue of Health Affairs.
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FRIDAY, Jan. 11, 2019 -- High intake of fiber is associated with a reduced risk for several noncommunicable diseases (NCDs), according to research published online Jan. 10 in the The Lancet.
THURSDAY, Jan. 10, 2019 -- A deep learning-based visual evaluation algorithm can detect cervical precancer/cancer with higher accuracy than conventional cytology, according to a study published online Jan. 10 in the Journal of the National Cancer Institute.
THURSDAY, Jan. 10, 2019 -- Older people who have less slow wave sleep have higher levels of the brain protein tau, a marker of brain damage and Alzheimer disease (AD), according to a study published in the Jan. 9 issue of Science Translational Medicine.
WEDNESDAY, Jan. 9, 2019 -- Obesity is associated with lower gray matter brain volumes, according to a study published online Jan. 9 in Neurology.
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WEDNESDAY, Jan. 9, 2019 -- Many U.S. female health care workers, particularly women of color, live in poverty and lack health insurance, according to a study published online Dec. 20 in the American Journal of Public Health.
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WEDNESDAY, Jan. 9, 2019 -- Intracoronary (IC) administration of nicardipine seems to be highly effective in reversing spontaneous coronary slow-flow (CSF), according to a study published online Dec. 15 in the Journal of Invasive Cardiology.
TUESDAY, Jan. 8, 2019 -- The U.S. Preventive Services Task Force (USPSTF) recommends hepatitis B virus (HBV) infection screening in pregnant women at their first prenatal visit. These findings form the basis of a draft recommendation statement published online Jan. 8 by the task force.
TUESDAY, Jan. 8, 2019 -- Certain molecular biomarkers for Alzheimer's disease differ with race, according to a study published online Jan. 7 in JAMA Neurology.
TUESDAY, Jan. 8, 2019 -- Less than two-thirds of eligible 30- to 65-year-old women are up to date with cervical cancer screening, and Pap completion rates have decreased over time, according to a study published online Jan. 7 in the Journal of Women's Health.
TUESDAY, Jan. 8, 2019 -- Eliminating the Affordable Care Act's individual mandate penalty is unlikely to destabilize the individual market in California but could roll back coverage gains, according to a study published in the January issue of Health Affairs.
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MONDAY, Jan. 7, 2019 -- Screening donated blood for Zika virus is cost-effective only in the high mosquito season in Puerto Rico, according to a study published online Jan. 8 in the Annals of Internal Medicine.
MONDAY, Jan. 7, 2019 -- Prescribed opioids are associated with an increased risk for community-acquired pneumonia (CAP) requiring hospitalization among persons with and without HIV, according to a study published online Jan. 7 in JAMA Internal Medicine.
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MONDAY, Jan. 7, 2019 -- Survivors of childhood Hodgkin lymphoma (HL) remain at increased risk for developing subsequent malignant neoplasms (SMNs), according to research published online Dec. 17 in Cancer.
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FRIDAY, Jan. 4, 2019 -- Sex differences have been identified in response to therapy among glioblastoma (GBM) patients, according to a study published in the Jan. 2 issue of Science Translational Medicine.
THURSDAY, Jan. 3, 2019 -- Newborn genomic sequencing (nGS) can detect the risk for disease onset during childhood and actionable adult-onset disease, according to a study published in the Jan. 3 issue of the American Journal of Human Genetics.
THURSDAY, Jan. 3, 2019 -- In patients without broad-definition anemia and/or abdominal mass, flexible sigmoidoscopy (FS), instead of colonoscopy, may suffice to rule out colorectal cancer, according to a study published online Dec. 19 in the British Journal of Cancer.
WEDNESDAY, Jan. 2, 2019 -- An American doctor is being treated at a Nebraska medical center for possible exposure to the Ebola virus while providing medical care in the Democratic Republic of Congo, which is in the middle of an Ebola outbreak that has left more than 300 dead.
WEDNESDAY, Jan. 2, 2019 -- A considerable proportion of cancer cases in men and women are attributable to excess body weight (EBW), with variation in the proportion among states, according to a study published online Dec. 27 in JAMA Oncology.
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Posted: February 2019