Huntington's disease is an autosomal dominant condition that typically presents in midlife as a combination of motor, cognitive, and psychiatric problems, along with sleep and metabolic abnormalities. Its clinical course runs over 15–20 years and eventually leads to death as patients develop dementia and become bed-bound. At present, no disease-modifying therapy is approved for patients with Huntington's disease. Although research on antisense therapies that target the huntingtin gene has generated much excitement, these therapies have not yet been shown to lead to measurable changes in disease progression.
Original Article: [Comment] The hunt for better treatments for Huntington's disease