Articles Radiotherapy plus cisplatin or cetuximab in lowrisk human papillomaviruspositive oropharyngeal cancer DeESCALaTE HPV an openlabel randomised controlled phase 3 trial

[Articles] Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial

Compared with the standard cisplatin regimen, cetuximab showed no benefit in terms of reduced toxicity, but instead showed significant detriment in terms of tumour control. Cisplatin and radiotherapy should be used as the standard of care for HPV-positive low-risk patients who are able to tolerate cisplatin.

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