Are you TORCing tau me Amyloidbeta blocks the conversation between lysosomes and mitochondria

Are you TORCing tau me? Amyloid-{beta} blocks the conversation between lysosomes and mitochondria

15:19 EST 15 Nov 2018 | Nature Publishing

How amyloid-β (Aβ) and tau exacerbate Alzheimer's disease (AD) at a subcellular level is only incompletely understood. Norambuena et al (2018) report crosstalk between mitochondria and lysosomes and identify a role for lysosomal mTORC1 in the nutrient-induced activation of mitochondria. This lysosomal signalling pathway is strongly inhibited by oligomeric Aβ through the tau-dependent activation of plasma membrane-localized mTORC1. Together, these results identify a further role for tau in mediating Aβ toxicity.

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